Immune Co-inhibitory Receptors PD-1, CTLA-4, TIM-3, LAG-3, and TIGIT in Medullary Thyroid Cancers: A Large Cohort Study

• Published in: The journal of clinical endocrinology and metabolism Vol. 106; no. 1; pp. 120 - 132
• Main Authors: Shi, Xiao, Li, Cui-Wei, Tan, Li-Cheng, Wen, Shi-Shuai, Liao, Tian, Zhang, Yan, Chen, Tong-Zhen, Ma, Ben, Yu, Peng-Cheng, Lu, Zhong-Wu, Qu, Ning, Wang, Yu, Shi, Rong-Liang, Wang, Yu-Long, Ji, Qing-Hai, Wei, Wen-Jun
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 01.01.2021; Copyright Oxford University Press
• Subjects: Analysis; Antigens; Apoptosis; Cancer; Cancer therapies; Care and treatment; CD223 antigen; Cell activation; Cell death; CTLA-4 protein; Cytotoxicity; DNA microarrays; Health aspects; Immune response; Immunogenicity; Immunoglobulins; Immunohistochemistry; Immunotherapy; Lymphocytes T; Oncology, Experimental; Patients; PD-1 protein; PD-L1 protein; Proteins; Rankings; T cells; Thyroid cancer; Thyroid carcinoma; Thyroid gland; Vandetanib; China; PD-L1; immune co-inhibitory receptors; CTLA-4; medullary thyroid carcinoma; TIM-3; PD-1

Abstract Context Programmed cell death protein-1 (PD-1), cytotoxic T-lymphocyte antigen 4 (CTLA-4), T-cell immunoglobulin and mucin-domain containing-3 (TIM-3), lymphocyte activation gene-3 (LAG-3), and T-cell immunoglobulin and ITIM domain (TIGIT) are considered major immune co-inhibitory receptors...