Efficacy of immunotherapy targeting the neoantigen derived from epidermal growth factor receptor T790M/C797S mutation in non–small cell lung cancer - Akazawa, Yu; Saito, Yuki; Yoshikawa, Toshiaki; Saito, Keigo; Nosaka, Kazuto; Shimomura, Manami; Mizuno, Shoichi; Nakamoto, Yasunari; Nakatsura, Tetsuya (Cancer science, 2020)
Keywords: Acrylamides - pharmacology; Acrylamides - therapeutic use; Aniline Compounds - pharmacology; Aniline Compounds - therapeutic use; Animals; Antibodies; Antigens; Antigens, Neoplasm - administration & dosage; Antigens, Neoplasm - genetics; Antigens, Neoplasm - immunology; C797S mutation; Cancer therapies; Cancer Vaccines - administration & dosage; Cancer Vaccines - genetics; Cancer Vaccines - immunology; Carcinoma, Non-Small-Cell Lung - drug therapy; Carcinoma, Non-Small-Cell Lung - genetics; Carcinoma, Non-Small-Cell Lung - immunology; Cell Line, Tumor; Chemotherapy; Cloning; Cytotoxicity; Drug Resistance, Neoplasm - genetics; Drug Resistance, Neoplasm - immunology; EGFR T790M; Enzyme-linked immunosorbent assay; Enzymes; Epidermal growth factor; Epidermal growth factor receptors; Epitopes, T-Lymphocyte - genetics; Epitopes, T-Lymphocyte - immunology; ErbB Receptors - antagonists & inhibitors; ErbB Receptors - genetics; ErbB Receptors - immunology; Histocompatibility antigen HLA; HLA-A2 Antigen - genetics; HLA-A2 Antigen - immunology; Humans; Immunotherapy; Immunotherapy - methods; Interferon; Kinases; Lung cancer; Lung Neoplasms - drug therapy; Lung Neoplasms - genetics; Lung Neoplasms - immunology; Lymphocytes T; Medical prognosis; Methionine; Mice; Mice, Knockout; Mutation; neoantigen; Neoantigens; Non-small cell lung carcinoma; non–small cell lung cancer; Original; Patients; Penicillin; Peptides; Peripheral blood mononuclear cells; Protein Kinase Inhibitors - pharmacology; Protein Kinase Inhibitors - therapeutic use; Protein-tyrosine kinase; Serine; Small cell lung carcinoma; T-Lymphocytes, Cytotoxic - immunology; Threonine; Vaccines, Subunit - administration & dosage; Vaccines, Subunit - genetics; Vaccines, Subunit - immunology; Japan; C797S mutation; neoantigen; non-small cell lung cancer; EGFR T790M; immunotherapy