Targeted exosome‐encapsulated erastin induced ferroptosis in triple negative breast cancer cells

• Published in: Cancer science Vol. 110; no. 10; pp. 3173 - 3182
• Main Authors: Yu, Mengyu, Gai, Chengcheng, Li, Zihaoran, Ding, Dejun, Zheng, Jie, Zhang, Weifen, Lv, Shijun, Li, Wentong
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.10.2019; John Wiley and Sons Inc
• Subjects: Apoptosis; Biocompatibility; Biotechnology; Breast cancer; Cancer therapies; Cell Death; Cell growth; Cell Line, Tumor; Cell Movement - drug effects; Cell proliferation; Cell Proliferation - drug effects; Cell Survival - drug effects; Chemotherapy; Cysteine dioxygenase; Cysteine Dioxygenase - metabolism; Cytotoxicity; Drug delivery; Drug Delivery Systems; Drugs; erastin; Exosomes; Exosomes - chemistry; Ferroptosis; Folic acid; Folic Acid - chemistry; Gene Expression Regulation, Neoplastic - drug effects; Glutamic acid transporter; Glutathione peroxidase; Glutathione Peroxidase - metabolism; Humans; Immunogenicity; Internalization; Lipids; Microscopy; Molecular weight; Nanotechnology; Original; Peroxide; Phospholipid Hydroperoxide Glutathione Peroxidase; Piperazines - chemistry; Piperazines - pharmacology; Proteins; Reactive oxygen species; Reactive Oxygen Species - metabolism; Toxicity; triple negative breast cancer; Triple Negative Breast Neoplasms - drug therapy; Triple Negative Breast Neoplasms - metabolism; Ultrasonic imaging; erastin; triple negative breast cancer; ferroptosis; exosomes; reactive oxygen species

Ferroptosis is an iron‐dependent, lipid peroxide‐driven cell death caused by inhibition of the cystine/glutamate transporter, which is of importance for the survival of triple‐negative breast cancer (TNBC) cells. Erastin is a low molecular weight chemotherapy drug that induces ferroptosis; however,...