离子交换固相萃取-超高效液相色谱-串联质谱法同时测定动物组织中的8类非甾体抗炎药残留
采用离子交换固相萃取-超高效液相色谱-串联质谱法同时测定了动物组织中的8类14种非甾体抗炎药（Non-steroidal anti-inflammatory drugs,NSAIDs）残留。动物组织样品经乙腈-乙酸乙酯（1∶1,V/V）提取、乙腈饱和正己烷除脂、Oasis MCX阳离子交换固相萃取柱除杂后,用液相色谱-质谱联用仪电喷雾电离,多反应监测模式检测。本方法的检出限为3.0～10.0μg/kg;定量限为10.0～25.0μg/kg;添加浓度在10.0～1000.0μg/kg范围内,牛肉组织中的回收率为62.9%～108.4%,相对标准偏差小于10%;猪肉组织中的回收率为63.4%～11...
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| Published in | 分析化学 Vol. 40; no. 2; pp. 236 - 242 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | Chinese |
| Published |
中国农业大学动物医学院,北京,100193%中国检验检疫科学研究院,北京,100123%山西大学化学化工学院,太原,030006
2012
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0253-3820 |
| DOI | 10.3724/SP.J.1096.2012.10597 |
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| Abstract | 采用离子交换固相萃取-超高效液相色谱-串联质谱法同时测定了动物组织中的8类14种非甾体抗炎药（Non-steroidal anti-inflammatory drugs,NSAIDs）残留。动物组织样品经乙腈-乙酸乙酯（1∶1,V/V）提取、乙腈饱和正己烷除脂、Oasis MCX阳离子交换固相萃取柱除杂后,用液相色谱-质谱联用仪电喷雾电离,多反应监测模式检测。本方法的检出限为3.0～10.0μg/kg;定量限为10.0～25.0μg/kg;添加浓度在10.0～1000.0μg/kg范围内,牛肉组织中的回收率为62.9%～108.4%,相对标准偏差小于10%;猪肉组织中的回收率为63.4%～117.0%,相对标准偏差小于9%。 |
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| AbstractList | S859.84; 采用离子交换固相萃取-超高效液相色谱-串联质谱法同时测定了动物组织中的8类14种非甾体抗炎药(Non-steroidal anti-inflammatory drugs,NSAIDs)残留.动物组织样品经乙腈-乙酸乙酯(1∶1,V/V)提取、乙腈饱和正己烷除脂、Oasis MCX阳离子交换固相萃取柱除杂后,用液相色谱-质谱联用仪电喷雾电离,多反应监测模式检测.本方法的检出限为3.0～10.0μg/kg;,定量限为10.0～25.0 μg/kg;添加浓度在10.0～1000.0 μg/kg范围内,牛肉组织中的回收率为62.9％～108.4％,相对标准偏差小于10％；猪肉组织中的回收率为63.4％～117.0％,相对标准偏差小于9％. 采用离子交换固相萃取-超高效液相色谱-串联质谱法同时测定了动物组织中的8类14种非甾体抗炎药（Non-steroidal anti-inflammatory drugs,NSAIDs）残留。动物组织样品经乙腈-乙酸乙酯（1∶1,V/V）提取、乙腈饱和正己烷除脂、Oasis MCX阳离子交换固相萃取柱除杂后,用液相色谱-质谱联用仪电喷雾电离,多反应监测模式检测。本方法的检出限为3.0～10.0μg/kg;定量限为10.0～25.0μg/kg;添加浓度在10.0～1000.0μg/kg范围内,牛肉组织中的回收率为62.9%～108.4%,相对标准偏差小于10%;猪肉组织中的回收率为63.4%～117.0%,相对标准偏差小于9%。 |
| Author | 胡婷 彭涛 李晓娟 陈冬东 代汉慧 周瑚宁 夏曦 丁双阳 朱爱玲 江海洋 |
| AuthorAffiliation | 中国农业大学动物医学院,北京100193 中国检验检疫科学研究院,北京100123 山西大学化学化工学院,太原030006 |
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| Author_FL | ZHOU Yue-Ning JIANG Hai-Yang LI Xiao-Juan CHEN Dong-Dong HU Ting DAI Han-Hui DING Shuang-Yang XIA Xi PENG Tao ZHU Ai-Ling |
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| DocumentTitleAlternate | Ion Exchange Solid Phase Extraction Coupled with Liquid Chromatography Tandem Mass Spectrometry for Determination of 8 Classes of Non-steroidal Anti-inflammatory Drugs Residues in Animal Tissues |
| DocumentTitle_FL | Ion Exchange Solid Phase Extraction Coupled with Liquid Chromatography Tandem Mass Spectrometry for Determination of 8 Classes of Non-steroidal Antiinflammatory Drugs Residues in Animal Tissues |
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| Keywords | 超高效液相色谱-串联质谱 非甾体抗炎药 多残留 动物组织 离子交换固相萃取 |
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| Notes | Non-steroidal anti-inflammatory drugs; Ion exchange solid phase extraction; Ultra performance liquid chromatography tandem mass spectrometry; Multi-residue; Animal tissues 22-1125/O6 An ultraperformance liquid chromatography tandem mass spectrometric（UPLC-MS/MS） method was established for the simultaneous determination of residues of 8 classes of 14 non-steroidal anti-inflammatory drugs（NSAIDs） in animal tissues.The samples were extracted with acetonitrile-ethyl acetate（1 ∶ 1,V/V）,defatted with n-hexane,and then purified by MCX solid phase extraction（SPE） cartridge.Analysis was carried out on UPLC-ESI-MS/MS working with multiple reaction monitoring mode with polarity switching.Limits of detection were between 3.0 μg/kg and 10.0 μg/kg,and limits of quantification were between 10.0 μg/kg and 25.0 μg/kg.At spiked levels of 10.0-1000.0 μg/kg,in bovine and swine muscle the recoveries were 62.9%-108.4% and 63.4%-117.0%,respectively,and relative standard deviations（RSD） of the method were less than 10% and 9%,respecti |
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| PublicationYear | 2012 |
| Publisher | 中国农业大学动物医学院,北京,100193%中国检验检疫科学研究院,北京,100123%山西大学化学化工学院,太原,030006 |
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| Snippet | 采用离子交换固相萃取-超高效液相色谱-串联质谱法同时测定了动物组织中的8类14种非甾体抗炎药（Non-steroidal anti-inflammatory drugs,NSAIDs）残留。动物组织样品经乙腈-乙酸乙酯（1∶1,V/V）提取、乙腈饱和正己烷除脂、Oasis... S859.84; 采用离子交换固相萃取-超高效液相色谱-串联质谱法同时测定了动物组织中的8类14种非甾体抗炎药(Non-steroidal anti-inflammatory drugs,NSAIDs)残留.动物组织样品经乙腈-乙酸乙酯(1∶1,V/V)提取、乙腈饱和正己烷除脂、Oasis... |
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| StartPage | 236 |
| SubjectTerms | 动物组织 多残留 离子交换固相萃取 超高效液相色谱-串联质谱 非甾体抗炎药 |
| Title | 离子交换固相萃取-超高效液相色谱-串联质谱法同时测定动物组织中的8类非甾体抗炎药残留 |
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