Circulating microRNAs and prediction of asthma exacerbation in childhood asthma

• Published in: Respiratory research Vol. 19; no. 1; pp. 128 - 9
• Main Authors: Kho, Alvin T., McGeachie, Michael J., Moore, Kip G., Sylvia, Jody M., Weiss, Scott T., Tantisira, Kelan G.
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 26.06.2018; BioMed Central; BMC
• Subjects: Airway management; AKT protein; Analysis; Asthma; Asthma - blood; Asthma - diagnosis; Asthma - genetics; Asthma exacerbation; Asthma in children; Bioinformatics; Biomarker; Biomarkers; Biomarkers - blood; Child; Child, Preschool; Childhood; Children; Chronic illnesses; Circulating microRNA; Circulating MicroRNA - blood; Circulating MicroRNA - genetics; Corticoids; Corticosteroids; Disease Progression; Double-Blind Method; Epigenetics; Female; Gene expression; Gene Expression Profiling - methods; Genetic aspects; Humans; Male; MicroRNA; MicroRNAs; miRNA; Predictions; Predictive Value of Tests; Prognosis; Randomization; Regression models; Ribonucleic acid; RNA; Smooth muscle; Studies; United States > US; Circulating microRNA; Asthma exacerbation; Biomarker

Circulating microRNAs have shown promise as non-invasive biomarkers and predictors of disease activity. Prior asthma studies using clinical, biochemical and genomic data have not shown excellent prediction of exacerbation. We hypothesized that a panel of circulating microRNAs in a pediatric asthma c...