Abnormalities in ileal stem, neurogenin 3, and enteroendocrine cells in patients with irritable bowel syndrome

• Published in: BMC gastroenterology Vol. 17; no. 1; pp. 90 - 9
• Main Authors: El-Salhy, Magdy, Gilja, Odd Helge
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 01.08.2017; BioMed Central; BMC
• Subjects: Abnormalities; Adolescent; Adult; Age; Aged; Basic Helix-Loop-Helix Transcription Factors - analysis; Biopsy; Case-Control Studies; Celiac disease; Cell density; Chromogranin A - analysis; Colon; Colonoscopy; Complications and side effects; Constipation; Development and progression; Diarrhea; Disease; Endocrine cells; Endocrinology; Enteroendocrine cells; Enteroendocrine Cells - metabolism; Female; Gastroenterology; Genetic aspects; Humans; IBS; Ileum; Ileum - cytology; Ileum - pathology; Image processing; Immunoglobulins; Immunohistochemistry; Intestine; Irritable bowel syndrome; Irritable Bowel Syndrome - metabolism; Irritable Bowel Syndrome - pathology; Male; Males; Middle Aged; Motility; Musashi protein; Mushasi-1; Nerve Tissue Proteins - analysis; Neurogenin 3; Neurogenins; Oxyntomodulin - analysis; Pancreatic Polypeptide - analysis; Peptide YY - analysis; Polypeptides; RNA-Binding Proteins - analysis; Rodents; Serotonin; Serotonin - analysis; Small intestine; Somatostatin; Somatostatin - analysis; Stem cells; Stem Cells - metabolism; Stem Cells - pathology; Young Adult; Norway; Immunohistochemistry; PYY; Serotonin; IBS; Ileum; Enteroendocrine cells; Mushasi-1; Neurogenin 3

This study examined whether the densities of stem- and enteroendocrine cell progenitors are abnormal in the ileum of patients with irritable bowel syndrome (IBS), and whether any abnormalities in ileal enteroendocrine cells are correlated with abnormalities in stem cells and enteroendocrine cell pro...