Targeting the Notch1 oncogene by miR-139-5p inhibits glioma metastasis and epithelial-mesenchymal transition (EMT)

• Published in: BMC neurology Vol. 18; no. 1; pp. 133 - 13
• Main Authors: Li, Jianlong, Li, Qingbin, Lin, Lin, Wang, Rui, Chen, Lingchao, Du, Wenzhong, Jiang, Chuanlu, Li, Ruiyan
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 31.08.2018; BioMed Central; BMC
• Subjects: Apoptosis; Brain cancer; Cadherins; Cancer therapies; Cell cycle; Chemoresistance; EMT; Epithelial cells; Genetic aspects; Glioma; Glioma cells; Gliomas; Immunofluorescence; Immunohistochemistry; Liver cancer; Medical prognosis; Mesenchyme; Metastases; Metastasis; MicroRNA; MicroRNAs; miR-139-5p; miRNA; N-Cadherin; Notch1; Notch1 protein; Oncogenes; Prognosis; Reversion; Risk factors; siRNA; Snail protein; Transcription; Tumors; Wound healing; Glioma; Notch1; EMT; miR-139-5p

Glioma metastasis, invasion, epithelial-mesenchymal transition (EMT) and chemoresistance indicate poor prognosis. Accumulating evidence reveals that Notch1 is an important factor in tumour progression. However, the role of Notch1 in glioma EMT and associated microRNAs (miRNAs) with the Notch pathway...