Fluid management in patients undergoing cardiac surgery: effects of an acetate- versus lactate-buffered balanced infusion solution on hemodynamic stability (HEMACETAT)

• Published in: Critical care (London, England) Vol. 23; no. 1; p. 159
• Main Authors: Pfortmueller, Carmen A, Faeh, Livia, Müller, Martin, Eberle, Balthasar, Jenni, Hansjörg, Zante, Björn, Prazak, Josef, Englberger, Lars, Takala, Jukka, Jakob, Stephan M
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 06.05.2019; BioMed Central; BMC
• Subjects: Aged; Analysis; Blood; Blood Gas Analysis; Buffers; Cardiac patients; Cardiac surgical procedures; Cardiac Surgical Procedures - methods; Cardiac Surgical Procedures - standards; Clinical trials; Comparative analysis; Critical care; Crystalloid solutions; Disease; Double-Blind Method; Drug dosages; Female; Flow velocity; Fluid therapy; Fluid Therapy - methods; Fluid Therapy - standards; Fluids; Health aspects; Heart surgery; Heart valve diseases; Hemodialysis; Hemodynamics; Hemodynamics - drug effects; Homeostasis; Humans; Intensive care; Isotonic Solutions - adverse effects; Isotonic Solutions - pharmacology; Isotonic Solutions - therapeutic use; Lactates; Linear Models; Liver; Liver diseases; Male; Medical research; Metabolism; Middle Aged; Monitoring, Physiologic - methods; Monitoring, Physiologic - statistics & numerical data; Patients; Randomized controlled trial; Ringer's Lactate - adverse effects; Ringer's Lactate - pharmacology; Ringer's Lactate - therapeutic use; Sepsis; Time Factors; Vasoconstrictor agents; Switzerland; Perioperative period; Cardiac surgical procedures; Fluid therapy; Crystalloid solutions; Vasoconstrictor agents; Hemodynamics; Randomized controlled trial

Recent evidence suggests that acetate-buffered infusions result in better hemodynamic stabilization than 0.9% saline in patients undergoing major surgery. The choice of buffer in balanced crystalloid solutions may modify their hemodynamic effects. We therefore compared the inopressor requirements of...