Genome-wide RNAseq study of the molecular mechanisms underlying microglia activation in response to pathological tau perturbation in the rTg4510 tau transgenic animal model

• Published in: Molecular neurodegeneration Vol. 13; no. 1; pp. 65 - 19
• Main Authors: Wang, Hong, Li, Yupeng, Ryder, John W., Hole, Justin T., Ebert, Philip J., Airey, David C., Qian, Hui-Rong, Logsdon, Benjamin, Fisher, Alice, Ahmed, Zeshan, Murray, Tracey K., Cavallini, Annalisa, Bose, Suchira, Eastwood, Brian J., Collier, David A., Dage, Jeffrey L., Miller, Bradley B., Merchant, Kalpana M., O’Neill, Michael J., Demattos, Ronald B.
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 17.12.2018; BioMed Central; BMC
• Subjects: Alzheimer Disease - genetics; Alzheimer Disease - metabolism; Alzheimer's disease; Animals; Apolipoprotein E; Brain; Brain - metabolism; Central nervous system; Cytokines; Data processing; Disease Models, Animal; Gene expression; Gene Expression - physiology; Gene Regulatory Networks - genetics; Genetic Predisposition to Disease; Genomes; Glutamatergic transmission; Inflammation; Innate immunity; Mice, Transgenic; Microglia; Microglia - metabolism; Molecular modelling; Morphology; Mutation; Nervous system; Neurodegeneration; Neuroinflammation; NF-κB protein; Oxidative phosphorylation; Pathogenesis; Pathology; Phosphorylation; RelA protein; Ribonucleic acid; RNA; RNAseq; Rodents; rTg4510; Signal transduction; Stat1 protein; Stat6 protein; Statistical analysis; Statistics; Synapses; Tau protein; tau Proteins - genetics; tau Proteins - metabolism; Tauopathy; Transcription factors; Transgenic animals; Transgenic mice; Neuroinflammation; Alzheimer’s disease; rTg4510; Tauopathy; RNAseq; Microglia

Activation of microglia, the resident immune cells of the central nervous system, is a prominent pathological hallmark of Alzheimer's disease (AD). However, the gene expression changes underlying microglia activation in response to tau pathology remain elusive. Furthermore, it is not clear how...