Progression of arterial stiffness is associated with changes in bone mineral markers in advanced CKD

• Published in: BMC nephrology Vol. 18; no. 1; p. 281
• Main Authors: Krishnasamy, Rathika, Tan, Sven-Jean, Hawley, Carmel M, Johnson, David W, Stanton, Tony, Lee, Kevin, Mudge, David W, Campbell, Scott, Elder, Grahame J, Toussaint, Nigel D, Isbel, Nicole M
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 04.09.2017; BioMed Central; BMC
• Subjects: Aged; Aorta; Aortic calcification; Arterial stiffness; Arteriosclerosis; Atherosclerosis; Biomarkers - blood; Body mass; Body mass index; Bone Density - physiology; Calcification; Calcification (ectopic); Calcium phosphates; Cardiovascular disease; Cardiovascular diseases; Chronic kidney disease; Chronic kidney failure; Coronary vessels; Development and progression; Dialysis; Disease Progression; Epidermal growth factor receptors; Female; Fibroblast growth factor 23; Fibroblast growth factors; Fibroblast Growth Factors - blood; Fibroblasts; Follow-Up Studies; Glomerular filtration rate; Glomerular Filtration Rate - physiology; Growth factors; Homeostasis; Humans; Ischemia; Kidney diseases; Kidney transplantation; Klotho protein; Laboratories; Longitudinal Studies; Male; Metabolism; Middle Aged; Mortality; Nephrology; Parathyroid; Parathyroid hormone; Prospective Studies; Proteins; Pulse Wave Analysis - methods; Radiography; Renal Insufficiency, Chronic - blood; Renal Insufficiency, Chronic - diagnostic imaging; Risk factors; Smooth muscle; Soluble klotho; Urine; Vascular Stiffness - physiology; Soluble klotho; Chronic kidney disease; Aortic calcification; Arterial stiffness; Fibroblast growth factor 23

Arterial stiffness is an independent predictor of all-cause and cardiovascular mortality in patients with chronic kidney disease (CKD). There are limited prospective data however on progression of arterial stiffness in CKD, including evaluating associations with bone mineral markers such as fibrobla...