Progression of arterial stiffness is associated with changes in bone mineral markers in advanced CKD
Arterial stiffness is an independent predictor of all-cause and cardiovascular mortality in patients with chronic kidney disease (CKD). There are limited prospective data however on progression of arterial stiffness in CKD, including evaluating associations with bone mineral markers such as fibrobla...
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Published in | BMC nephrology Vol. 18; no. 1; p. 281 |
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Main Authors | , , , , , , , , , , |
Format | Journal Article |
Language | English |
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BioMed Central Ltd
04.09.2017
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Abstract | Arterial stiffness is an independent predictor of all-cause and cardiovascular mortality in patients with chronic kidney disease (CKD). There are limited prospective data however on progression of arterial stiffness in CKD, including evaluating associations with bone mineral markers such as fibroblast growth factor 23 (FGF23) and soluble α-klotho (sKl).
In this prospective, single-center, observational study, arterial stiffness [measured by pulse wave velocity (PWV)] and hormones influencing mineral homeostasis, including serum FGF23 and sKl, were compared between non-dialysis CKD stages 4/5 and healthy controls at baseline and 12 months (12 m). Abdominal aortic calcification (AAC) was quantitated using lateral lumbar radiography at baseline.
Forty patients with CKD [mean estimated glomerular filtration rate (eGFR) 19.5 ± 6.7 mL/min/1.73m
] and 42 controls (mean eGFR 88.6 ± 12.9 mL/min/1.73m
) completed follow-up. There were no differences in age, gender and body mass index between groups. A significant increase in FGF23 [240.6 (141.9-1129.8) to 396.8 (160.3-997.7) pg/mL, p = 0.001] was observed in the CKD group but serum phosphate, corrected calcium, parathyroid hormone and sKl did not change significantly over 12 m. At baseline, CKD subjects had higher AAC prevalence [83.8% versus (vs.) 43.6%, p = 0.002] and higher aortic PWV [9.7(7.6-11.7) vs. 8.1 (7.2-9.7) m/s, p = 0.047] compared to controls. At 12 m, aortic PWV increased by 1.3 m/s (95% confidence interval, 0.56 to 2.08, p < 0.001) in the CKD cohort, with 30% of subjects showing progression from normal aortic elasticity to stiffening (PWV > 10 m/s). Serum FGF23 was associated with AAC, abnormal PWV and progression of PWV at 12 m.
Arterial stiffness and serum FGF23, both of which are associated with increased cardiovascular risk, increased over one year in individuals with CKD. Additionally, a significant association was found between serum FGF23 and arterial calcification and stiffness. Larger clinical studies and further experimental work are warranted to delineate the temporal relationship as well as the pathological mechanisms linking FGF23 and vascular disease. |
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AbstractList | Arterial stiffness is an independent predictor of all-cause and cardiovascular mortality in patients with chronic kidney disease (CKD). There are limited prospective data however on progression of arterial stiffness in CKD, including evaluating associations with bone mineral markers such as fibroblast growth factor 23 (FGF23) and soluble [alpha]-klotho (sKl). In this prospective, single-center, observational study, arterial stiffness [measured by pulse wave velocity (PWV)] and hormones influencing mineral homeostasis, including serum FGF23 and sKl, were compared between non-dialysis CKD stages 4/5 and healthy controls at baseline and 12 months (12 m). Abdominal aortic calcification (AAC) was quantitated using lateral lumbar radiography at baseline. Forty patients with CKD [mean estimated glomerular filtration rate (eGFR) 19.5 [+ or -] 6.7 mL/min/1.73m.sup.2] and 42 controls (mean eGFR 88.6 [+ or -] 12.9 mL/min/1.73m.sup.2) completed follow-up. There were no differences in age, gender and body mass index between groups. A significant increase in FGF23 [240.6 (141.9-1129.8) to 396.8 (160.3-997.7) pg/mL, p = 0.001] was observed in the CKD group but serum phosphate, corrected calcium, parathyroid hormone and sKl did not change significantly over 12 m. At baseline, CKD subjects had higher AAC prevalence [83.8% versus (vs.) 43.6%, p = 0.002] and higher aortic PWV [9.7(7.6-11.7) vs. 8.1 (7.2-9.7) m/s, p = 0.047] compared to controls. At 12 m, aortic PWV increased by 1.3 m/s (95% confidence interval, 0.56 to 2.08, p < 0.001) in the CKD cohort, with 30% of subjects showing progression from normal aortic elasticity to stiffening (PWV > 10 m/s). Serum FGF23 was associated with AAC, abnormal PWV and progression of PWV at 12 m. Arterial stiffness and serum FGF23, both of which are associated with increased cardiovascular risk, increased over one year in individuals with CKD. Additionally, a significant association was found between serum FGF23 and arterial calcification and stiffness. Larger clinical studies and further experimental work are warranted to delineate the temporal relationship as well as the pathological mechanisms linking FGF23 and vascular disease. BACKGROUNDArterial stiffness is an independent predictor of all-cause and cardiovascular mortality in patients with chronic kidney disease (CKD). There are limited prospective data however on progression of arterial stiffness in CKD, including evaluating associations with bone mineral markers such as fibroblast growth factor 23 (FGF23) and soluble α-klotho (sKl).METHODSIn this prospective, single-center, observational study, arterial stiffness [measured by pulse wave velocity (PWV)] and hormones influencing mineral homeostasis, including serum FGF23 and sKl, were compared between non-dialysis CKD stages 4/5 and healthy controls at baseline and 12 months (12 m). Abdominal aortic calcification (AAC) was quantitated using lateral lumbar radiography at baseline.RESULTSForty patients with CKD [mean estimated glomerular filtration rate (eGFR) 19.5 ± 6.7 mL/min/1.73m2] and 42 controls (mean eGFR 88.6 ± 12.9 mL/min/1.73m2) completed follow-up. There were no differences in age, gender and body mass index between groups. A significant increase in FGF23 [240.6 (141.9-1129.8) to 396.8 (160.3-997.7) pg/mL, p = 0.001] was observed in the CKD group but serum phosphate, corrected calcium, parathyroid hormone and sKl did not change significantly over 12 m. At baseline, CKD subjects had higher AAC prevalence [83.8% versus (vs.) 43.6%, p = 0.002] and higher aortic PWV [9.7(7.6-11.7) vs. 8.1 (7.2-9.7) m/s, p = 0.047] compared to controls. At 12 m, aortic PWV increased by 1.3 m/s (95% confidence interval, 0.56 to 2.08, p < 0.001) in the CKD cohort, with 30% of subjects showing progression from normal aortic elasticity to stiffening (PWV > 10 m/s). Serum FGF23 was associated with AAC, abnormal PWV and progression of PWV at 12 m.CONCLUSIONSArterial stiffness and serum FGF23, both of which are associated with increased cardiovascular risk, increased over one year in individuals with CKD. Additionally, a significant association was found between serum FGF23 and arterial calcification and stiffness. Larger clinical studies and further experimental work are warranted to delineate the temporal relationship as well as the pathological mechanisms linking FGF23 and vascular disease. Arterial stiffness is an independent predictor of all-cause and cardiovascular mortality in patients with chronic kidney disease (CKD). There are limited prospective data however on progression of arterial stiffness in CKD, including evaluating associations with bone mineral markers such as fibroblast growth factor 23 (FGF23) and soluble α-klotho (sKl). In this prospective, single-center, observational study, arterial stiffness [measured by pulse wave velocity (PWV)] and hormones influencing mineral homeostasis, including serum FGF23 and sKl, were compared between non-dialysis CKD stages 4/5 and healthy controls at baseline and 12 months (12 m). Abdominal aortic calcification (AAC) was quantitated using lateral lumbar radiography at baseline. Forty patients with CKD [mean estimated glomerular filtration rate (eGFR) 19.5 ± 6.7 mL/min/1.73m ] and 42 controls (mean eGFR 88.6 ± 12.9 mL/min/1.73m ) completed follow-up. There were no differences in age, gender and body mass index between groups. A significant increase in FGF23 [240.6 (141.9-1129.8) to 396.8 (160.3-997.7) pg/mL, p = 0.001] was observed in the CKD group but serum phosphate, corrected calcium, parathyroid hormone and sKl did not change significantly over 12 m. At baseline, CKD subjects had higher AAC prevalence [83.8% versus (vs.) 43.6%, p = 0.002] and higher aortic PWV [9.7(7.6-11.7) vs. 8.1 (7.2-9.7) m/s, p = 0.047] compared to controls. At 12 m, aortic PWV increased by 1.3 m/s (95% confidence interval, 0.56 to 2.08, p < 0.001) in the CKD cohort, with 30% of subjects showing progression from normal aortic elasticity to stiffening (PWV > 10 m/s). Serum FGF23 was associated with AAC, abnormal PWV and progression of PWV at 12 m. Arterial stiffness and serum FGF23, both of which are associated with increased cardiovascular risk, increased over one year in individuals with CKD. Additionally, a significant association was found between serum FGF23 and arterial calcification and stiffness. Larger clinical studies and further experimental work are warranted to delineate the temporal relationship as well as the pathological mechanisms linking FGF23 and vascular disease. Background Arterial stiffness is an independent predictor of all-cause and cardiovascular mortality in patients with chronic kidney disease (CKD). There are limited prospective data however on progression of arterial stiffness in CKD, including evaluating associations with bone mineral markers such as fibroblast growth factor 23 (FGF23) and soluble α-klotho (sKl). Methods In this prospective, single-center, observational study, arterial stiffness [measured by pulse wave velocity (PWV)] and hormones influencing mineral homeostasis, including serum FGF23 and sKl, were compared between non-dialysis CKD stages 4/5 and healthy controls at baseline and 12 months (12 m). Abdominal aortic calcification (AAC) was quantitated using lateral lumbar radiography at baseline. Results Forty patients with CKD [mean estimated glomerular filtration rate (eGFR) 19.5 ± 6.7 mL/min/1.73m2] and 42 controls (mean eGFR 88.6 ± 12.9 mL/min/1.73m2) completed follow-up. There were no differences in age, gender and body mass index between groups. A significant increase in FGF23 [240.6 (141.9-1129.8) to 396.8 (160.3-997.7) pg/mL, p = 0.001] was observed in the CKD group but serum phosphate, corrected calcium, parathyroid hormone and sKl did not change significantly over 12 m. At baseline, CKD subjects had higher AAC prevalence [83.8% versus (vs.) 43.6%, p = 0.002] and higher aortic PWV [9.7(7.6-11.7) vs. 8.1 (7.2-9.7) m/s, p = 0.047] compared to controls. At 12 m, aortic PWV increased by 1.3 m/s (95% confidence interval, 0.56 to 2.08, p < 0.001) in the CKD cohort, with 30% of subjects showing progression from normal aortic elasticity to stiffening (PWV > 10 m/s). Serum FGF23 was associated with AAC, abnormal PWV and progression of PWV at 12 m. Conclusions Arterial stiffness and serum FGF23, both of which are associated with increased cardiovascular risk, increased over one year in individuals with CKD. Additionally, a significant association was found between serum FGF23 and arterial calcification and stiffness. Larger clinical studies and further experimental work are warranted to delineate the temporal relationship as well as the pathological mechanisms linking FGF23 and vascular disease. Background Arterial stiffness is an independent predictor of all-cause and cardiovascular mortality in patients with chronic kidney disease (CKD). There are limited prospective data however on progression of arterial stiffness in CKD, including evaluating associations with bone mineral markers such as fibroblast growth factor 23 (FGF23) and soluble [alpha]-klotho (sKl). Methods In this prospective, single-center, observational study, arterial stiffness [measured by pulse wave velocity (PWV)] and hormones influencing mineral homeostasis, including serum FGF23 and sKl, were compared between non-dialysis CKD stages 4/5 and healthy controls at baseline and 12 months (12 m). Abdominal aortic calcification (AAC) was quantitated using lateral lumbar radiography at baseline. Results Forty patients with CKD [mean estimated glomerular filtration rate (eGFR) 19.5 [+ or -] 6.7 mL/min/1.73m.sup.2] and 42 controls (mean eGFR 88.6 [+ or -] 12.9 mL/min/1.73m.sup.2) completed follow-up. There were no differences in age, gender and body mass index between groups. A significant increase in FGF23 [240.6 (141.9-1129.8) to 396.8 (160.3-997.7) pg/mL, p = 0.001] was observed in the CKD group but serum phosphate, corrected calcium, parathyroid hormone and sKl did not change significantly over 12 m. At baseline, CKD subjects had higher AAC prevalence [83.8% versus (vs.) 43.6%, p = 0.002] and higher aortic PWV [9.7(7.6-11.7) vs. 8.1 (7.2-9.7) m/s, p = 0.047] compared to controls. At 12 m, aortic PWV increased by 1.3 m/s (95% confidence interval, 0.56 to 2.08, p < 0.001) in the CKD cohort, with 30% of subjects showing progression from normal aortic elasticity to stiffening (PWV > 10 m/s). Serum FGF23 was associated with AAC, abnormal PWV and progression of PWV at 12 m. Conclusions Arterial stiffness and serum FGF23, both of which are associated with increased cardiovascular risk, increased over one year in individuals with CKD. Additionally, a significant association was found between serum FGF23 and arterial calcification and stiffness. Larger clinical studies and further experimental work are warranted to delineate the temporal relationship as well as the pathological mechanisms linking FGF23 and vascular disease. Keywords: Aortic calcification, Arterial stiffness, Chronic kidney disease, Fibroblast growth factor 23, Soluble klotho Abstract Background Arterial stiffness is an independent predictor of all-cause and cardiovascular mortality in patients with chronic kidney disease (CKD). There are limited prospective data however on progression of arterial stiffness in CKD, including evaluating associations with bone mineral markers such as fibroblast growth factor 23 (FGF23) and soluble α-klotho (sKl). Methods In this prospective, single-center, observational study, arterial stiffness [measured by pulse wave velocity (PWV)] and hormones influencing mineral homeostasis, including serum FGF23 and sKl, were compared between non-dialysis CKD stages 4/5 and healthy controls at baseline and 12 months (12 m). Abdominal aortic calcification (AAC) was quantitated using lateral lumbar radiography at baseline. Results Forty patients with CKD [mean estimated glomerular filtration rate (eGFR) 19.5 ± 6.7 mL/min/1.73m2] and 42 controls (mean eGFR 88.6 ± 12.9 mL/min/1.73m2) completed follow-up. There were no differences in age, gender and body mass index between groups. A significant increase in FGF23 [240.6 (141.9–1129.8) to 396.8 (160.3–997.7) pg/mL, p = 0.001] was observed in the CKD group but serum phosphate, corrected calcium, parathyroid hormone and sKl did not change significantly over 12 m. At baseline, CKD subjects had higher AAC prevalence [83.8% versus (vs.) 43.6%, p = 0.002] and higher aortic PWV [9.7(7.6–11.7) vs. 8.1 (7.2–9.7) m/s, p = 0.047] compared to controls. At 12 m, aortic PWV increased by 1.3 m/s (95% confidence interval, 0.56 to 2.08, p < 0.001) in the CKD cohort, with 30% of subjects showing progression from normal aortic elasticity to stiffening (PWV > 10 m/s). Serum FGF23 was associated with AAC, abnormal PWV and progression of PWV at 12 m. Conclusions Arterial stiffness and serum FGF23, both of which are associated with increased cardiovascular risk, increased over one year in individuals with CKD. Additionally, a significant association was found between serum FGF23 and arterial calcification and stiffness. Larger clinical studies and further experimental work are warranted to delineate the temporal relationship as well as the pathological mechanisms linking FGF23 and vascular disease. |
ArticleNumber | 281 |
Audience | Academic |
Author | Krishnasamy, Rathika Lee, Kevin Isbel, Nicole M Tan, Sven-Jean Hawley, Carmel M Toussaint, Nigel D Stanton, Tony Mudge, David W Campbell, Scott Elder, Grahame J Johnson, David W |
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BackLink | https://www.ncbi.nlm.nih.gov/pubmed/28870151$$D View this record in MEDLINE/PubMed |
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Cites_doi | 10.1097/01.ASN.0000145894.57533.C4 10.1006/bbrc.1998.8943 10.1681/ASN.2005101085 10.1016/j.jacc.2009.02.047 10.1016/j.bbrc.2005.11.094 10.1152/ajpendo.00264.2014 10.1186/1471-2369-14-241 10.1681/ASN.2007010068 10.1046/j.1523-1755.2002.00170.x 10.1371/journal.pone.0056695 10.1371/journal.pone.0044161 10.1046/j.1523-1755.2002.00625.x 10.1681/ASN.2006070783 10.1093/ndt/gfq293 10.1038/ki.2009.24 10.1038/ki.2013.332 10.1038/ki.2013.3 10.1177/0004563213510708 10.1016/j.jacc.2009.10.061 10.1111/jch.12198 10.1172/JCI61405 10.1006/bbrc.2000.4226 10.1159/000331737 10.1038/sj.ki.5001589 10.1111/j.1474-9726.2012.00796.x 10.1016/S0021-9150(97)00106-8 10.1681/ASN.2009121311 10.1249/mss.0b013e3180616aa2 10.1093/ndt/gfl718 10.1161/HYPERTENSIONAHA.112.197210 10.1159/000353593 10.1161/01.HYP.33.5.1111 10.1172/JCI46122 10.1111/nep.12268 10.1172/JCI200419081 10.1136/heartjnl-2013-304746 10.1152/ajpendo.00596.2012 10.1097/HJH.0b013e32834fa8b0 10.1038/36285 10.7326/0003-4819-150-9-200905050-00006 10.1007/s00198-011-1838-0 10.1016/j.atherosclerosis.2009.01.001 10.1161/01.CIR.99.18.2434 10.1074/jbc.M304544200 |
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Keywords | Soluble klotho Chronic kidney disease Aortic calcification Arterial stiffness Fibroblast growth factor 23 |
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PublicationYear | 2017 |
Publisher | BioMed Central Ltd BioMed Central BMC |
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References | 17494882 - J Am Soc Nephrol. 2007 Jun;18(6):1637-47 16325773 - Biochem Biophys Res Commun. 2006 Jan 20;339(3):827-32 17205962 - Nephrol Dial Transplant. 2007 Apr;22(4):1171-6 24088960 - Kidney Int. 2014 May;85(5):1103-11 23431388 - PLoS One. 2013;8(2):e56695 20501463 - Nephrol Dial Transplant. 2010 Dec;25(12):4041-8 9675134 - Biochem Biophys Res Commun. 1998 Jul 20;248(2):324-9 22970174 - PLoS One. 2012;7(9):e44161 20338492 - J Am Coll Cardiol. 2010 Mar 30;55(13):1318-27 24269946 - Ann Clin Biochem. 2014 Mar;51(Pt 2):203-27 24750549 - Nephrology (Carlton). 2014 Aug;19(8):439-49 12371973 - Kidney Int. 2002 Nov;62(5):1724-31 21115613 - J Am Soc Nephrol. 2011 Jan;22(1):124-36 19181315 - Atherosclerosis. 2009 Aug;205(2):385-90 23090769 - Hypertension. 2012 Dec;60(6):1451-7 11162628 - Biochem Biophys Res Commun. 2001 Feb 2;280(4):1015-20 19414839 - Ann Intern Med. 2009 May 5;150(9):604-12 19497438 - J Am Coll Cardiol. 2009 Jun 9;53(23):2129-40 14966565 - J Clin Invest. 2004 Feb;113(4):561-8 21985788 - J Clin Invest. 2011 Nov;121(11):4393-408 16738019 - J Am Soc Nephrol. 2006 Jul;17(7):2034-47 9242971 - Atherosclerosis. 1997 Jul 25;132(2):245-50 22728934 - J Clin Invest. 2012 Jul;122(7):2543-53 21865732 - Cell Physiol Biochem. 2011;28(2):251-8 24102750 - J Clin Hypertens (Greenwich). 2013 Nov;15(11):833-8 25053401 - Am J Physiol Endocrinol Metab. 2014 Sep 1;307(5):E426-36 24180481 - BMC Nephrol. 2013 Nov 01;14:241 17762378 - Med Sci Sports Exerc. 2007 Aug;39(8):1435-45 17855636 - J Am Soc Nephrol. 2007 Oct;18(10):2683-8 10334796 - Hypertension. 1999 May;33(5):1111-7 22278144 - J Hypertens. 2012 Mar;30(3):445-8 24165855 - Heart. 2014 Jan;100(1):34-40 23443925 - Am J Physiol Endocrinol Metab. 2013 Apr 15;304(8):E863-73 23389416 - Kidney Int. 2013 Jun;83(6):1159-68 15579497 - J Am Soc Nephrol. 2004 Dec;15(12):2959-64 9363890 - Nature. 1997 Nov 6;390(6655):45-51 19225558 - Kidney Int. 2009 Jun;75(11):1166-72 11849407 - Kidney Int. 2002 Feb;61(2):638-47 12874285 - J Biol Chem. 2003 Sep 26;278(39):37419-26 16775593 - Kidney Int. 2006 Aug;70(3):543-8 22260450 - Aging Cell. 2012 Jun;11(3):410-7 23942553 - Nephron Clin Pract. 2013;123(3-4):194-201 22109743 - Osteoporos Int. 2012 Jul;23(7):2017-25 10318666 - Circulation. 1999 May 11;99(18):2434-9 CM Giachelli (705_CR5) 2004; 15 A Karras (705_CR4) 2012; 60 N Koh (705_CR13) 2001; 280 MA Mirza (705_CR28) 2009; 205 T Shimada (705_CR11) 2004; 113 J Blacher (705_CR21) 1999; 33 JP Schwaiger (705_CR2) 2006; 70 SM Moe (705_CR7) 2002; 61 ME Nelson (705_CR19) 2007; 39 LI Kauppila (705_CR23) 1997; 132 Y Saito (705_CR42) 1998; 248 ER Smith (705_CR40) 2014; 51 B Dai (705_CR39) 2012; 7 C Faul (705_CR36) 2011; 121 LM Bortel Van (705_CR22) 2012; 30 MC Hu (705_CR43) 2011; 22 Y Wang (705_CR41) 2012; 11 R Jimbo (705_CR17) 2014; 85 M Dermaku-Sopjani (705_CR15) 2011; 28 M Ikushima (705_CR16) 2006; 339 L Desjardins (705_CR30) 2012; 23 JF Navarro-Gonzalez (705_CR44) 2014; 100 AS Levey (705_CR20) 2009; 150 M Kitagawa (705_CR45) 2013; 8 L Craver (705_CR12) 2007; 22 SJ Tan (705_CR14) 2014; 19 S Liu (705_CR8) 2003; 278 JJ Scialla (705_CR29) 2013; 83 M Kuro-o (705_CR33) 1997; 390 M Ohnishi (705_CR32) 2009; 75 S Tholen (705_CR27) 2013; 15 N Silswal (705_CR34) 2014; 307 T Kawata (705_CR10) 2007; 18 M Tonelli (705_CR1) 2006; 17 C Vlachopoulos (705_CR24) 2010; 55 J Blacher (705_CR25) 1999; 99 CD Touchberry (705_CR35) 2013; 304 FG Hage (705_CR3) 2009; 53 A Ozkok (705_CR31) 2013; 14 JY Jung (705_CR26) 2010; 25 S Liu (705_CR9) 2007; 18 NX Chen (705_CR6) 2002; 62 Welfare AIoHa (705_CR18) 2003 V Shalhoub (705_CR37) 2012; 122 CP Kovesdy (705_CR38) 2013; 123 |
References_xml | – volume: 15 start-page: 2959 issue: 12 year: 2004 ident: 705_CR5 publication-title: Journal of the American Society of Nephrology : JASN doi: 10.1097/01.ASN.0000145894.57533.C4 contributor: fullname: CM Giachelli – volume: 248 start-page: 324 issue: 2 year: 1998 ident: 705_CR42 publication-title: Biochem Biophys Res Commun doi: 10.1006/bbrc.1998.8943 contributor: fullname: Y Saito – volume: 17 start-page: 2034 issue: 7 year: 2006 ident: 705_CR1 publication-title: J Am Soc Nephrol doi: 10.1681/ASN.2005101085 contributor: fullname: M Tonelli – volume: 53 start-page: 2129 issue: 23 year: 2009 ident: 705_CR3 publication-title: J Am Coll Cardiol doi: 10.1016/j.jacc.2009.02.047 contributor: fullname: FG Hage – volume: 339 start-page: 827 issue: 3 year: 2006 ident: 705_CR16 publication-title: Biochem Biophys Res Commun doi: 10.1016/j.bbrc.2005.11.094 contributor: fullname: M Ikushima – volume: 307 start-page: E426 issue: 5 year: 2014 ident: 705_CR34 publication-title: Am J Phys Endocrinol Metab doi: 10.1152/ajpendo.00264.2014 contributor: fullname: N Silswal – volume: 14 start-page: 241 year: 2013 ident: 705_CR31 publication-title: BMC Nephrol doi: 10.1186/1471-2369-14-241 contributor: fullname: A Ozkok – volume: 18 start-page: 1637 issue: 6 year: 2007 ident: 705_CR9 publication-title: J Am Soc Nephrol doi: 10.1681/ASN.2007010068 contributor: fullname: S Liu – volume: 61 start-page: 638 issue: 2 year: 2002 ident: 705_CR7 publication-title: Kidney Int doi: 10.1046/j.1523-1755.2002.00170.x contributor: fullname: SM Moe – volume: 8 issue: 2 year: 2013 ident: 705_CR45 publication-title: PLoS One doi: 10.1371/journal.pone.0056695 contributor: fullname: M Kitagawa – volume: 7 issue: 9 year: 2012 ident: 705_CR39 publication-title: PLoS One doi: 10.1371/journal.pone.0044161 contributor: fullname: B Dai – volume: 62 start-page: 1724 issue: 5 year: 2002 ident: 705_CR6 publication-title: Kidney Int doi: 10.1046/j.1523-1755.2002.00625.x contributor: fullname: NX Chen – volume: 18 start-page: 2683 issue: 10 year: 2007 ident: 705_CR10 publication-title: J Am Soc Nephrol doi: 10.1681/ASN.2006070783 contributor: fullname: T Kawata – volume: 25 start-page: 4041 issue: 12 year: 2010 ident: 705_CR26 publication-title: Nephrol Dial Transplant doi: 10.1093/ndt/gfq293 contributor: fullname: JY Jung – volume: 75 start-page: 1166 issue: 11 year: 2009 ident: 705_CR32 publication-title: Kidney Int doi: 10.1038/ki.2009.24 contributor: fullname: M Ohnishi – volume: 85 start-page: 1103 issue: 5 year: 2014 ident: 705_CR17 publication-title: Kidney Int doi: 10.1038/ki.2013.332 contributor: fullname: R Jimbo – volume: 83 start-page: 1159 issue: 6 year: 2013 ident: 705_CR29 publication-title: Kidney Int doi: 10.1038/ki.2013.3 contributor: fullname: JJ Scialla – volume: 51 start-page: 203 issue: Pt 2 year: 2014 ident: 705_CR40 publication-title: Ann Clin Biochem doi: 10.1177/0004563213510708 contributor: fullname: ER Smith – volume: 55 start-page: 1318 issue: 13 year: 2010 ident: 705_CR24 publication-title: J Am Coll Cardiol doi: 10.1016/j.jacc.2009.10.061 contributor: fullname: C Vlachopoulos – volume: 15 start-page: 833 issue: 11 year: 2013 ident: 705_CR27 publication-title: J Clin Hypertens doi: 10.1111/jch.12198 contributor: fullname: S Tholen – volume: 122 start-page: 2543 issue: 7 year: 2012 ident: 705_CR37 publication-title: J Clin Invest doi: 10.1172/JCI61405 contributor: fullname: V Shalhoub – volume: 280 start-page: 1015 issue: 4 year: 2001 ident: 705_CR13 publication-title: Biochem Biophys Res Commun doi: 10.1006/bbrc.2000.4226 contributor: fullname: N Koh – volume: 28 start-page: 251 issue: 2 year: 2011 ident: 705_CR15 publication-title: Cell Physiol Biochem doi: 10.1159/000331737 contributor: fullname: M Dermaku-Sopjani – volume: 70 start-page: 543 issue: 3 year: 2006 ident: 705_CR2 publication-title: Kidney Int doi: 10.1038/sj.ki.5001589 contributor: fullname: JP Schwaiger – volume: 11 start-page: 410 issue: 3 year: 2012 ident: 705_CR41 publication-title: Aging Cell doi: 10.1111/j.1474-9726.2012.00796.x contributor: fullname: Y Wang – volume: 132 start-page: 245 issue: 2 year: 1997 ident: 705_CR23 publication-title: Atherosclerosis doi: 10.1016/S0021-9150(97)00106-8 contributor: fullname: LI Kauppila – volume: 22 start-page: 124 issue: 1 year: 2011 ident: 705_CR43 publication-title: Journal of the American Society of Nephrology : JASN doi: 10.1681/ASN.2009121311 contributor: fullname: MC Hu – volume: 39 start-page: 1435 issue: 8 year: 2007 ident: 705_CR19 publication-title: Med Sci Sports Exerc doi: 10.1249/mss.0b013e3180616aa2 contributor: fullname: ME Nelson – volume: 22 start-page: 1171 issue: 4 year: 2007 ident: 705_CR12 publication-title: Nephrol Dial Transplant doi: 10.1093/ndt/gfl718 contributor: fullname: L Craver – volume-title: The active Australia survey: a guide andmanual for implementation, analysis and reporting year: 2003 ident: 705_CR18 contributor: fullname: Welfare AIoHa – volume: 60 start-page: 1451 issue: 6 year: 2012 ident: 705_CR4 publication-title: Hypertension doi: 10.1161/HYPERTENSIONAHA.112.197210 contributor: fullname: A Karras – volume: 123 start-page: 194 issue: 3–4 year: 2013 ident: 705_CR38 publication-title: Nephron Clinical practice doi: 10.1159/000353593 contributor: fullname: CP Kovesdy – volume: 33 start-page: 1111 issue: 5 year: 1999 ident: 705_CR21 publication-title: Hypertension doi: 10.1161/01.HYP.33.5.1111 contributor: fullname: J Blacher – volume: 121 start-page: 4393 issue: 11 year: 2011 ident: 705_CR36 publication-title: J Clin Invest doi: 10.1172/JCI46122 contributor: fullname: C Faul – volume: 19 start-page: 439 issue: 8 year: 2014 ident: 705_CR14 publication-title: Nephrology doi: 10.1111/nep.12268 contributor: fullname: SJ Tan – volume: 113 start-page: 561 issue: 4 year: 2004 ident: 705_CR11 publication-title: J Clin Invest doi: 10.1172/JCI200419081 contributor: fullname: T Shimada – volume: 100 start-page: 34 issue: 1 year: 2014 ident: 705_CR44 publication-title: Heart doi: 10.1136/heartjnl-2013-304746 contributor: fullname: JF Navarro-Gonzalez – volume: 304 start-page: E863 issue: 8 year: 2013 ident: 705_CR35 publication-title: Am J Phys Endocrinol Metab doi: 10.1152/ajpendo.00596.2012 contributor: fullname: CD Touchberry – volume: 30 start-page: 445 issue: 3 year: 2012 ident: 705_CR22 publication-title: J Hypertens doi: 10.1097/HJH.0b013e32834fa8b0 contributor: fullname: LM Bortel Van – volume: 390 start-page: 45 issue: 6655 year: 1997 ident: 705_CR33 publication-title: Nature doi: 10.1038/36285 contributor: fullname: M Kuro-o – volume: 150 start-page: 604 issue: 9 year: 2009 ident: 705_CR20 publication-title: Ann Intern Med doi: 10.7326/0003-4819-150-9-200905050-00006 contributor: fullname: AS Levey – volume: 23 start-page: 2017 issue: 7 year: 2012 ident: 705_CR30 publication-title: Osteoporos Int doi: 10.1007/s00198-011-1838-0 contributor: fullname: L Desjardins – volume: 205 start-page: 385 issue: 2 year: 2009 ident: 705_CR28 publication-title: Atherosclerosis doi: 10.1016/j.atherosclerosis.2009.01.001 contributor: fullname: MA Mirza – volume: 99 start-page: 2434 issue: 18 year: 1999 ident: 705_CR25 publication-title: Circulation doi: 10.1161/01.CIR.99.18.2434 contributor: fullname: J Blacher – volume: 278 start-page: 37419 issue: 39 year: 2003 ident: 705_CR8 publication-title: J Biol Chem doi: 10.1074/jbc.M304544200 contributor: fullname: S Liu |
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Snippet | Arterial stiffness is an independent predictor of all-cause and cardiovascular mortality in patients with chronic kidney disease (CKD). There are limited... Background Arterial stiffness is an independent predictor of all-cause and cardiovascular mortality in patients with chronic kidney disease (CKD). There are... BACKGROUNDArterial stiffness is an independent predictor of all-cause and cardiovascular mortality in patients with chronic kidney disease (CKD). There are... Abstract Background Arterial stiffness is an independent predictor of all-cause and cardiovascular mortality in patients with chronic kidney disease (CKD).... |
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SubjectTerms | Aged Aorta Aortic calcification Arterial stiffness Arteriosclerosis Atherosclerosis Biomarkers - blood Body mass Body mass index Bone Density - physiology Calcification Calcification (ectopic) Calcium phosphates Cardiovascular disease Cardiovascular diseases Chronic kidney disease Chronic kidney failure Coronary vessels Development and progression Dialysis Disease Progression Epidermal growth factor receptors Female Fibroblast growth factor 23 Fibroblast growth factors Fibroblast Growth Factors - blood Fibroblasts Follow-Up Studies Glomerular filtration rate Glomerular Filtration Rate - physiology Growth factors Homeostasis Humans Ischemia Kidney diseases Kidney transplantation Klotho protein Laboratories Longitudinal Studies Male Metabolism Middle Aged Mortality Nephrology Parathyroid Parathyroid hormone Prospective Studies Proteins Pulse Wave Analysis - methods Radiography Renal Insufficiency, Chronic - blood Renal Insufficiency, Chronic - diagnostic imaging Risk factors Smooth muscle Soluble klotho Urine Vascular Stiffness - physiology |
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Title | Progression of arterial stiffness is associated with changes in bone mineral markers in advanced CKD |
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