Zeaxanthin improves diabetes-induced cognitive deficit in rats through activiting PI3K/AKT signaling pathway

• Published in: Brain research bulletin Vol. 132; pp. 190 - 198
• Main Authors: Zhou, Xiaoyan, Wang, Shanshan, Ding, Xin, Qin, Li, Mao, Yizhen, Chen, Lei, Li, Wei, Ying, Changjiang
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.06.2017
• Subjects: Active Transport, Cell Nucleus - drug effects; Active Transport, Cell Nucleus - physiology; AKT; Animals; Caspase 3 - metabolism; Cell Survival - drug effects; Cell Survival - physiology; Cognition Disorders - drug therapy; Cognition Disorders - enzymology; Cognition Disorders - etiology; Cognition Disorders - pathology; Cognitive deficit; Diabetes; Diabetes Mellitus, Experimental - drug therapy; Diabetes Mellitus, Experimental - enzymology; Diabetes Mellitus, Experimental - pathology; Diabetes Mellitus, Experimental - psychology; Hippocampus - drug effects; Hippocampus - enzymology; Hippocampus - pathology; Hypoglycemic Agents - chemistry; Hypoglycemic Agents - pharmacology; Male; Maze Learning - drug effects; Maze Learning - physiology; Neurology; Neurons - drug effects; Neurons - enzymology; Neurons - pathology; Neuroprotective Agents - chemistry; Neuroprotective Agents - pharmacology; NF-kappa B - metabolism; NF-κB; Nootropic Agents - chemistry; Nootropic Agents - pharmacology; Phosphatidylinositol 3-Kinases - metabolism; Proto-Oncogene Proteins c-akt - metabolism; Rats, Sprague-Dawley; Signal Transduction - drug effects; Zeaxanthin; Zeaxanthins - chemistry; Zeaxanthins - pharmacology; Zeaxanthin; NF-κB; AKT; Diabetes; Cognitive deficit

•Diabetes- induced cognitive deficit could be ameliorated by zeaxanthin.•Zeaxanthin could protect hippocampal neurons against hyperglycemia.•Zeaxanthin improved cognitive deficit through activating PI3K/AKT signaling pathway. Published studies have shown that cognitive deficit is a characteristic ma...