Enhanced chemosensory sensitivity in patients with idiopathic rhinitis and its reversal by nasal capsaicin treatment - Van Gerven, Laura; Alpizar, Yeranddy A.; Steelant, Brecht; Callebaut, Ina; Kortekaas Krohn, Inge; Wouters, Mira; Vermeulen, François; Boeckxstaens, Guy; Talavera, Karel; Hellings, Peter W. (Journal of allergy and clinical immunology, 2017)
Keywords: Administration, Intranasal; Adult; Allergies; Allergy and Immunology; Allyl isothiocyanate; Biopsy; Capsaicin; Capsaicin - administration & dosage; Capsaicin - pharmacology; Capsaicin - therapeutic use; Capsaicin receptors; Chemoreception; Clinical trials; Double-Blind Method; Female; Gene expression; Humans; Hyperreactivity; idiopathic rhinitis; Innervation; Investigations; Isothiocyanate; Isothiocyanates - pharmacology; Male; Middle Aged; Mucosa; nasal hyperreactivity; Nasal Mucosa - drug effects; Nasal Mucosa - metabolism; Nasal Mucosa - physiology; nasal mucosal potential; Nerve growth factor; Nerve Growth Factor - genetics; nonallergic rhinitis; Nose; Otolaryngology; Pain perception; Patients; Rhinitis; Rhinitis - drug therapy; Rhinitis - genetics; Rhinitis - physiopathology; RNA, Messenger - metabolism; Sensory neurons; Signal transduction; Substance P; Transient Receptor Potential Channels - agonists; Transient Receptor Potential Channels - genetics; Transient receptor potential proteins; treatment; Trigeminal nerve; TRPA1; TRPV1; Ubiquitin Thiolesterase - genetics; Visual perception; Young Adult; nasal hyperreactivity; treatment; TRPA1; Capsaicin; TRE; idiopathic rhinitis; AITC; IR; VAS; TRPV1; NGF; NANIR; nasal mucosal potential; nonallergic rhinitis; NMP; TRP; TSS; RT-PCR; SPT; NHR; HC; TRPM8; LAR; SP; Healthy control; Nerve growth factor; Allyl isothiocyanate; Total symptom score; Visual analog scale; Therapeutic response evaluation; Transient receptor potential cation channel subfamily V, receptor 1; Real-time PCR; Substance P; Skin prick test; Transient receptor potential; Nonallergic noninfectious rhinitis; Transient receptor potential cation channel subfamily M, member 8; Local allergic rhinitis; Transient receptor potential cation channel subfamily A, receptor 1