Molecular pathways of motor neuron injury in amyotrophic lateral sclerosis

• Published in: Nature reviews. Neurology Vol. 7; no. 11; pp. 616 - 630
• Main Authors: Ferraiuolo, Laura, Kirby, Janine, Grierson, Andrew J., Sendtner, Michael, Shaw, Pamela J.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.11.2011; Nature Publishing Group
• Subjects: 631/378/1689/1285; 631/378/2632/1664; 631/80/304; 692/699/578; Amyotrophic lateral sclerosis; Amyotrophic Lateral Sclerosis - genetics; Amyotrophic Lateral Sclerosis - metabolism; Amyotrophic Lateral Sclerosis - pathology; Cell death; Complications and side effects; Genes; Genetic aspects; Humans; Medicine; Medicine & Public Health; Motor Neurons - pathology; Mutation; Nerve Degeneration - genetics; Nerve Degeneration - metabolism; Nerve Degeneration - pathology; Neurology; Neurons; Neurosciences; Oxidative stress; Physiological aspects; Proteins; review-article; Risk factors; United Kingdom

An improved understanding of the cellular events that lead to motor neuron injury in amyotrophic lateral sclerosis (ALS) could highlight promising new therapeutic strategies. Pamela Shaw and colleagues provide a comprehensive overview of the numerous molecular mechanisms that are involved in ALS, in...