Bcl-2-associated athanogene 3(BAG3) is associated with tumor cell proliferation, migration, invasion and chemoresistance in colorectal cancer

• Published in: BMC cancer Vol. 18; no. 1; pp. 793 - 15
• Main Authors: Li, Ning, Chen, Minghong, Cao, Yansha, Li, Hua, Zhao, Jinping, Zhai, Zhenhua, Ren, Fu, Li, Keyan
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 06.08.2018; BioMed Central; BMC
• Subjects: Adaptor Proteins, Signal Transducing - genetics; Adaptor Proteins, Signal Transducing - metabolism; Aged; Antimetabolites, Antineoplastic - pharmacology; Apoptosis; Apoptosis Regulatory Proteins - genetics; Apoptosis Regulatory Proteins - metabolism; Autophagy; BAG3; Bcl-2 protein; Bioinformatics; Cell growth; Cell migration; Cell Movement - drug effects; Cell proliferation; Cell Proliferation - drug effects; Chemoresistance; Colorectal cancer; Colorectal carcinoma; Colorectal Neoplasms - drug therapy; Colorectal Neoplasms - genetics; Colorectal Neoplasms - metabolism; Colorectal Neoplasms - pathology; CRISPR; Drug resistance; Drug Resistance, Neoplasm - genetics; Female; Fluorouracil - pharmacology; Gene expression; Gene Expression Regulation, Neoplastic; Genetic aspects; HCT-116; HCT116 Cells; HIV; Human immunodeficiency virus; Humans; Infections; Invasion; Kinases; Male; Middle Aged; Migration; Neoplasm Invasiveness; Ovarian cancer; Proliferation; Proteins; Signal Transduction; Tumors; Up-Regulation; China; BAG3; Migration; Chemoresistance; Colorectal cancer; HCT-116; Proliferation; Microarray; Gene-interaction network; Invasion

CRC is one of the most common malignancies worldwide, and its molecular mechanisms remain unclear. Elevated levels of BAG3 have been reported in various tumors. The present study aimed to explore the expression and function of BAG3 in CRC. BAG3 protein expression was evaluated in 90 CRC specimens us...