Synthesis, Anti-Influenza H1N1 and Anti-Dengue Activity of A-Ring Modified Oleanonic Acid Polyamine Derivatives

• Published in: Molecules (Basel, Switzerland) Vol. 27; no. 23; p. 8499
• Main Authors: Smirnova, Irina, Petrova, Anastasiya, Giniyatullina, Gul'nara, Smirnova, Anna, Volobueva, Alexandrina, Pavlyukova, Julia, Zarubaev, Vladimir, Loc, Tran Van, Tran Thi Phoung, Thao, Hau, Vu Thi Bich, Thuy, Nguyen Thi Thu, Khine, Myint Myint, Kazakova, Oxana
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.12.2022; MDPI
• Subjects: Amides; Amides - therapeutic use; Amines; Antimicrobial agents; Antiviral activity; Antiviral agents; Antiviral Agents - therapeutic use; benzylidene; Cancer; Cell cycle; Cytotoxicity; Dengue; Dengue fever; E coli; Herbal medicine; Humans; indole; Influenza; Influenza A; Influenza A Virus, H1N1 Subtype; Influenza, Human - drug therapy; Methicillin; oleanolic acid; polyamine; Polyamines; Polyamines - pharmacology; Polyamines - therapeutic use; Selectivity; Serotypes; Severe acute respiratory syndrome coronavirus 2; Triterpenes - therapeutic use; triterpenoids; Ugi derivatives; Vector-borne diseases; Viruses; China; polyamine; influenza A (H1N1); indole; Ugi derivatives; oleanolic acid; triterpenoids; antiviral activity; Dengue virus; benzylidene

A series of sixteen A-ring modified (2,3-indolo-, 2-benzylidene) oleanonic acid derivatives, holding some cyclic amines, linear polyamines and benzylaminocarboxamides at C28, has been synthesized and screened for antiviral activity against influenza A/PuertoRico/8/34 (H1N1) and Dengue virus serotype...