Synthesis, Chiral Resolution and Enantiomers Absolute Configuration of 4-Nitropropranolol and 7-Nitropropranolol

• Published in: Molecules (Basel, Switzerland) Vol. 28; no. 1; p. 57
• Main Authors: Sparaco, Rosa, Scognamiglio, Antonia, Corvino, Angela, Caliendo, Giuseppe, Fiorino, Ferdinando, Magli, Elisa, Perissutti, Elisa, Santagada, Vincenzo, Severino, Beatrice, Luciano, Paolo, Casertano, Marcello, Aiello, Anna, De Nucci, Gilberto, Frecentese, Francesco
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 21.12.2022; MDPI
• Subjects: 4-nitropropranolol; 7-nitropropranolol; Acids; Catecholamines; chiral HPLC; Chromatography, High Pressure Liquid - methods; Dopamine; Enantiomers; Endothelium; Magnetic Resonance Spectroscopy; Methods; Nitration; NMR absolute configuration assignment; Propranolol; Propranolol hydrochloride; Riguera’s method; Sensors; Stereoisomerism; Massachusetts; United States > US; 4-nitropropranolol; 7-nitropropranolol; Riguera’s method; NMR absolute configuration assignment; chiral HPLC

We recently identified 6-nitrodopamine and other nitro-catecholamines (6-nitrodopa, 6-nitroadrenaline), indicating that the endothelium has the ability to nitrate the classical catecholamines (dopamine, noradrenaline, and adrenaline). In order to investigate whether drugs could be subject to the sam...