Evaluation of bone marrow-derived mesenchymal stem cell quality from patients with congenital pseudoarthrosis of the tibia

• Published in: Journal of orthopaedic surgery and research Vol. 13; no. 1; pp. 266 - 8
• Main Authors: Dilogo, Ismail Hadisoebroto, Mujadid, Fajar, Nurhayati, Retno Wahyu, Kurniawan, Aryadi
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 23.10.2018; BioMed Central; BMC
• Subjects: Adolescent; Adult; Autografts; Biomedical materials; Bone growth; Bone healing; Bone marrow; Bone Marrow Cells - pathology; Care and treatment; Cell differentiation; Cell Differentiation - physiology; Cell Proliferation - physiology; Cell Separation - methods; Cells, Cultured; Cellular Senescence - physiology; Flow Cytometry; Fractures; Health aspects; Humans; Iliac crest; Ilium - pathology; Mesenchymal stem cells; Mesenchymal Stem Cells - pathology; Mesenchyme; Methods; Middle Aged; Orthopedics; Osteocytes; Osteogenesis - physiology; Patients; Pediatrics; Phenotype; Phenotypes; Pseudarthrosis - congenital; Pseudarthrosis - pathology; Pseudoarthrosis; Quality; Regeneration; Senescence; Stem cells; Tibia; Tibia - pathology; Young Adult; United States > US; Indonesia; Pseudoarthrosis; Osteocytes; Cell differentiation; Mesenchymal stem cells

The treatment of congenital pseudoarthrosis of the tibia (CPT) remains challenging in pediatric orthopedics due to the difficulties in bone union, continuous angulation, joint stiffness, and severe limb length discrepancy. Mesenchymal stem cells (MSCs) therapy offers a complementary approach to impr...