The host cellular immune response to cytomegalovirus targets the endothelium and is associated with increased arterial stiffness in ANCA-associated vasculitis

• Published in: Arthritis research & therapy Vol. 20; no. 1; p. 194
• Main Authors: Chanouzas, Dimitrios, Sagmeister, Michael, Dyall, Lovesh, Sharp, Phoebe, Powley, Lucy, Johal, Serena, Bowen, Jessica, Nightingale, Peter, Ferro, Charles J, Morgan, Matthew D, Moss, Paul, Harper, Lorraine
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 29.08.2018; BioMed Central; BMC
• Subjects: Aged; ANCA; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - blood; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - diagnosis; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - immunology; Antigens; Arterial stiffness; Arthritis; Atherosclerosis; Cardiovascular disease; Care and treatment; Cohort Studies; Complications and side effects; Cytomegalovirus; Cytomegalovirus - immunology; Cytomegalovirus infections; Cytomegalovirus Infections - blood; Cytomegalovirus Infections - diagnosis; Cytomegalovirus Infections - immunology; Cytotoxicity; Development and progression; Endothelium; Endothelium, Vascular - immunology; Endothelium, Vascular - metabolism; Endothelium, Vascular - virology; Female; Gene expression; Genetic aspects; Genotype & phenotype; Health aspects; Health risk assessment; Hepatitis; Humans; Immune response; Immunity, Cellular - physiology; Infections; Inflammation; Lymphocytes; Male; Middle Aged; Mortality; Phenotypes; Pulse Wave Analysis - methods; Rheumatoid arthritis; T cells; TNF inhibitors; Tumor necrosis factor-TNF; Vascular Stiffness - physiology; Vasculitis; United Kingdom > UK; Cytomegalovirus; Vasculitis; Arterial stiffness; ANCA; Cardiovascular disease; Inflammation; T cells

Cardiovascular disease is a leading cause of death in ANCA-associated vasculitis (AAV). An expansion of CD4 CD28 T cells is seen mainly in cytomegalovirus (CMV)-seropositive individuals and has been linked to increased cardiovascular disease risk in other conditions. The aims of this study were to p...