6'-O-galloylpaeoniflorin regulates proliferation and metastasis of non-small cell lung cancer through AMPK/miR-299-5p/ATF2 axis

• Published in: Respiratory research Vol. 21; no. 1; pp. 39 - 15
• Main Authors: Gao, Jinying, Song, Lei, Xia, Huan, Peng, Liping, Wen, Zhongmei
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 03.02.2020; BioMed Central; BMC
• Subjects: 3' Untranslated regions; Activating transcription factor 2; AMP; AMP-activated protein kinase; Antioxidants; Assaying; ATF2; metastasis; Binding sites; Biocompatibility; Cancer metastasis; Cancer therapies; Cell culture; Cell cycle; Cell proliferation; Cellular signal transduction; Chemotherapy; Chinese herbal medicine; Composition; Cytotoxicity; Development and progression; Gene expression; Health aspects; In vivo methods and tests; Inflammation; Invasiveness; Kinases; Lung cancer; Medical prognosis; Metastases; Metastasis; MicroRNA; MicroRNAs; Non-small cell lung cancer; Non-small cell lung carcinoma; Oxidants; Oxidizing agents; Peonies; Plant extracts; Proliferation; Proteins; Radiation therapy; Scratch tests; Signal transduction; Small cell lung carcinoma; Testing; Toxicity; Western blotting; Xenografts; Xenotransplantation; China; United States > US; microRNA; Proliferation; ATF2; metastasis; Non-small cell lung cancer

Recent studies have shown 6'-O-galloylpaeoniflorin (GPF), a nature product extracted from the roots of paeoniflorin exerts anti-oxidant and anti-inflammatory activities. However, the effects of GPF on the proliferation and invasion in non-small cell lung cancer (NSCLC) cells have not been clari...