Effect of administration of triiodothyronine on aspartate aminotransferase in pyridoxine-deficient rats

• Published in: Journal of Nutritional Science and Vitaminology Vol. 30; no. 4; pp. 335 - 340
• Main Authors: Okada, M, Ikeda, M
• Format: Journal Article
• Language: English
• Published: Japan Center for Academic Publications Japan 01.01.1984
• Subjects: Animals; aspartate aminotransferase; Aspartate Aminotransferases; Aspartate Aminotransferases - metabolism; aspartate transaminase; Cytosol; Cytosol - enzymology; enzymology; Liver; Liver - enzymology; Malate Dehydrogenase; Malate Dehydrogenase - metabolism; Male; malic enzyme; metabolism; Mitochondria, Liver; Mitochondria, Liver - enzymology; nutrient deficiencies; pharmacology; physiopathology; pyridoxine; pyridoxine deficiency; Rats; Rats, Inbred Strains; thyroid function; Thyroid Gland; Thyroid Gland - physiopathology; triiodothyronine; triiodothyronine (T3) administration; Triiodothyronine - pharmacology; Vitamin B 6 Deficiency; Vitamin B 6 Deficiency - enzymology
• ISSN: 0301-4800; 1881-7742
• DOI: 10.3177/jnsv.30.335

The state of thyroid function and the effect of triiodothyronine (T3) administration on aspartate aminotransferase isozymes in the livers of rats fed on a diet with or without pyridoxine were examined. Decreased thyroid function in pyridoxine-deficient rats was demonstrated using malic enzyme as a marker of thyroid function in the liver. Administration of T3 increased cytosolic aspartate aminotransferase in the liver of pyridoxine-deficient rats, but not of control rats.