Effect of administration of triiodothyronine on aspartate aminotransferase in pyridoxine-deficient rats
The state of thyroid function and the effect of triiodothyronine (T3) administration on aspartate aminotransferase isozymes in the livers of rats fed on a diet with or without pyridoxine were examined. Decreased thyroid function in pyridoxine-deficient rats was demonstrated using malic enzyme as a m...
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| Published in | Journal of Nutritional Science and Vitaminology Vol. 30; no. 4; pp. 335 - 340 |
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| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
Japan
Center for Academic Publications Japan
01.01.1984
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| ISSN | 0301-4800 1881-7742 |
| DOI | 10.3177/jnsv.30.335 |
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| Abstract | The state of thyroid function and the effect of triiodothyronine (T3) administration on aspartate aminotransferase isozymes in the livers of rats fed on a diet with or without pyridoxine were examined. Decreased thyroid function in pyridoxine-deficient rats was demonstrated using malic enzyme as a marker of thyroid function in the liver. Administration of T3 increased cytosolic aspartate aminotransferase in the liver of pyridoxine-deficient rats, but not of control rats. |
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| AbstractList | The state of thyroid function and the effect of triiodothyronine (T3) administration on aspartate aminotransferase isozymes in the livers of rats fed on a diet with or without pyridoxine were examined. Decreased thyroid function in pyridoxine-deficient rats was demonstrated using malic enzyme as a marker of thyroid function in the liver. Administration of T3 increased cytosolic aspartate aminotransferase in the liver of pyridoxine-deficient rats, but not of control rats. The state of thyroid function and the effect of triiodothyronine (T3) administration on aspartate aminotransferase isozymes in the livers of rats fed on a diet with or without pyridoxine were examined. Decreased thyroid function in pyridoxine-deficient rats was demonstrated using malic enzyme as a marker of thyroid function in the liver. Administration of T3 increased cytosolic aspartate aminotransferase in the liver of pyridoxine-deficient rats, but not of control rats.The state of thyroid function and the effect of triiodothyronine (T3) administration on aspartate aminotransferase isozymes in the livers of rats fed on a diet with or without pyridoxine were examined. Decreased thyroid function in pyridoxine-deficient rats was demonstrated using malic enzyme as a marker of thyroid function in the liver. Administration of T3 increased cytosolic aspartate aminotransferase in the liver of pyridoxine-deficient rats, but not of control rats. |
| Author | Okada, M Ikeda, M |
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| References | 7) Kondo, T., Nagata, K., Shibuya, M., and Okada, M. (1982): Effect of pyridoxine deficiency on the synthesis of aspartate aminotransferase in rat liver and muscle in vivo. J. Biochem., 92, 1087-1091. 16) Karmen, A. (1955): A note on the spectrophotometric assay of glutamic oxalacetic transaminase in human blood. J. Clin. Invest., 34, 131-133. 6) Kuroda, K., Hirose, M., and Okada,, M. (1982): Increase of inactive form of aspartate aminotransferase in pyridoxine-deficient rat liver. J. Biochem., 92, 1079-1085. 20) Oppenheimer, J. H. (1979): Thyroid hormone action at the cellular level. Science, 203, 971-979. 2) Boyd, J. W. (1961): The intracellular distribution, latency and electrophoretic mobility of L-glutamate-oxaloacetate transaminase from rat liver. Biochem. J., 81, 434-441. 9) Cake, M. H., Disorbo, D. M., and Litwack, G. (1978): Effect of pyridoxal phosphate on the DNA binding site of activated hepatic glucocorticoid receptor. J. Biol. Chem., 253, 4886--4891. 1) Katunuma, N., Matsuzawa, T., and Huzino, A. (1962): Differences between the transaminases in mitochondria and soluble fraction. II. Glutamic-oxaloacetic trans aminase. J. Vitaminol., 8, 74-79. 15) Ochoa, S. (1955), Malic enzyme, in Methods in Enzymology, ed. by Colowick, S. P., and Kaplan, N. O., Vol. 1, Academic Press, New York, pp. 739-748. 23) Krushkova, A. M. (1974): The influence of thyroxine on the isozyme distribution of tissue aspartate aminotransferase in normal and thyroidectomized guinea pigs. Acta Biol. Med. Germ., 33, 43-47. 10) Disorbo, D. M., Phelps, D. S., Ohl, V. S., and Litwack, G. (1980): Pyridoxine deficiency influences the behavior of the glucocorticoid-receptor complex. J. Biol. Chem., 255, 3866-3870. 11) Disorbo, D. M., and Litwack, G. (1981): Changes in the intracellular levels of pyridoxal 5'-phosphate affect the induction of tyrosine aminotransferase by glucocorticoids. Biochem. Biophys. Res. Commun., 99, 1203-1208. 5) Okada, M., and Kondo, T. (1982): Effect of treatment with pyridoxine on aspartate aminotransferase activities in pyridoxine-deficient rat tissues. J. Nutr. Sci. Vitaminol., 28, 69-75. 21) Herzfeld, A., and Greengard, O. (1971): Aspartate aminotransferase in rat tissues: changes with growth and hormones. Biochim. Biophys. Acta, 237, 88-98. 24) Dakshinamurti, K., and Paulose, C. S. (1983): Consequences of brain monoamine changes in the pyridoxine-deficient neonate rat. International Symposium on Chemical and Biological Aspects of Vitamin B6Catalysis, in Greece, Abstract, p. 30. 4) Okada, M., and Hirose, M. (1979): Regulation of aspartate aminotransferase activity associated with change of pyridoxal phosphate level. Arch. Biochem. Biophys., 193, 294-300. 19) Szepsi, B., and Freedland, R. A. (1969): Effect of thyroid hormones on metabolism. IV. Comparative aspects of enzyme responses. Am. J. Physiol., 216, 1054-1056. 13) Kagamiyama, H. (1966): Studies on glutamic-oxalacetic transaminase (GOT) isozymes from pig heart. Med. J. Osaka Univ., 18, 171-181. 22) Sheid, B., and Roth, J. S. (1965): Some effects of hormones and L-aspartate on the activity and distribution of aspartate aminotransferase activity in rat liver, in Advences in Enzyme Regulation, ed. by Weber, G., Pergamon Press, New York, pp. 335-350. 3) Wada, H., and Morino, Y. (1964): Comparative studies on glutamic-oxalacetic transaminases from the mitochondrial and soluble fraction of mammalian tissues. Vitam. Horm., 22, 411-444. 18) Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J. (1951): Protein measurement with the Folin phenol reagent. J. Biol. Chem., 193, 265-275. 12) Okada, M., and Ochi, A. (1971): The effect of dietary protein level on transaminase activities and fat deposition in vitamin B6 depleted rat liver. J. Biochem., 70, 581-585. 14) Huynh, Q. K., Sakakibara, R., Watanabe, T., and Wada, H. (1980): Glutamic oxaloacetic transaminase isozymes from rat liver. Purification and physicochemical characterization. J. Biochem., 88, 231-239. 8) Shibuya, M., Nagata, K., and Okada, M. (1982): Effect of pyridoxine deficiency on activities and amounts of aspartate aminotransferase isozymes in rat tissues. J. Biochem., 92, 1399-1402. 17) Gornall, A. G., Bardawill, C. S., and David, M. M. (1949): Determination of serum proteins by means of the biuret reaction. J. Biol. Chem., 177, 751-766. |
| References_xml | – reference: 2) Boyd, J. W. (1961): The intracellular distribution, latency and electrophoretic mobility of L-glutamate-oxaloacetate transaminase from rat liver. Biochem. J., 81, 434-441. – reference: 17) Gornall, A. G., Bardawill, C. S., and David, M. M. (1949): Determination of serum proteins by means of the biuret reaction. J. Biol. Chem., 177, 751-766. – reference: 1) Katunuma, N., Matsuzawa, T., and Huzino, A. (1962): Differences between the transaminases in mitochondria and soluble fraction. II. Glutamic-oxaloacetic trans aminase. J. Vitaminol., 8, 74-79. – reference: 4) Okada, M., and Hirose, M. (1979): Regulation of aspartate aminotransferase activity associated with change of pyridoxal phosphate level. Arch. Biochem. Biophys., 193, 294-300. – reference: 11) Disorbo, D. M., and Litwack, G. (1981): Changes in the intracellular levels of pyridoxal 5'-phosphate affect the induction of tyrosine aminotransferase by glucocorticoids. Biochem. Biophys. Res. Commun., 99, 1203-1208. – reference: 18) Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J. (1951): Protein measurement with the Folin phenol reagent. J. Biol. Chem., 193, 265-275. – reference: 20) Oppenheimer, J. H. (1979): Thyroid hormone action at the cellular level. Science, 203, 971-979. – reference: 19) Szepsi, B., and Freedland, R. A. (1969): Effect of thyroid hormones on metabolism. IV. Comparative aspects of enzyme responses. Am. J. Physiol., 216, 1054-1056. – reference: 22) Sheid, B., and Roth, J. S. (1965): Some effects of hormones and L-aspartate on the activity and distribution of aspartate aminotransferase activity in rat liver, in Advences in Enzyme Regulation, ed. by Weber, G., Pergamon Press, New York, pp. 335-350. – reference: 12) Okada, M., and Ochi, A. (1971): The effect of dietary protein level on transaminase activities and fat deposition in vitamin B6 depleted rat liver. J. Biochem., 70, 581-585. – reference: 5) Okada, M., and Kondo, T. (1982): Effect of treatment with pyridoxine on aspartate aminotransferase activities in pyridoxine-deficient rat tissues. J. Nutr. Sci. Vitaminol., 28, 69-75. – reference: 23) Krushkova, A. M. (1974): The influence of thyroxine on the isozyme distribution of tissue aspartate aminotransferase in normal and thyroidectomized guinea pigs. Acta Biol. Med. Germ., 33, 43-47. – reference: 14) Huynh, Q. K., Sakakibara, R., Watanabe, T., and Wada, H. (1980): Glutamic oxaloacetic transaminase isozymes from rat liver. Purification and physicochemical characterization. J. Biochem., 88, 231-239. – reference: 24) Dakshinamurti, K., and Paulose, C. S. (1983): Consequences of brain monoamine changes in the pyridoxine-deficient neonate rat. International Symposium on Chemical and Biological Aspects of Vitamin B6Catalysis, in Greece, Abstract, p. 30. – reference: 8) Shibuya, M., Nagata, K., and Okada, M. (1982): Effect of pyridoxine deficiency on activities and amounts of aspartate aminotransferase isozymes in rat tissues. J. Biochem., 92, 1399-1402. – reference: 7) Kondo, T., Nagata, K., Shibuya, M., and Okada, M. (1982): Effect of pyridoxine deficiency on the synthesis of aspartate aminotransferase in rat liver and muscle in vivo. J. Biochem., 92, 1087-1091. – reference: 13) Kagamiyama, H. (1966): Studies on glutamic-oxalacetic transaminase (GOT) isozymes from pig heart. Med. J. Osaka Univ., 18, 171-181. – reference: 16) Karmen, A. (1955): A note on the spectrophotometric assay of glutamic oxalacetic transaminase in human blood. J. Clin. Invest., 34, 131-133. – reference: 10) Disorbo, D. M., Phelps, D. S., Ohl, V. S., and Litwack, G. (1980): Pyridoxine deficiency influences the behavior of the glucocorticoid-receptor complex. J. Biol. Chem., 255, 3866-3870. – reference: 15) Ochoa, S. (1955), Malic enzyme, in Methods in Enzymology, ed. by Colowick, S. P., and Kaplan, N. O., Vol. 1, Academic Press, New York, pp. 739-748. – reference: 3) Wada, H., and Morino, Y. (1964): Comparative studies on glutamic-oxalacetic transaminases from the mitochondrial and soluble fraction of mammalian tissues. Vitam. Horm., 22, 411-444. – reference: 9) Cake, M. H., Disorbo, D. M., and Litwack, G. (1978): Effect of pyridoxal phosphate on the DNA binding site of activated hepatic glucocorticoid receptor. J. Biol. Chem., 253, 4886--4891. – reference: 6) Kuroda, K., Hirose, M., and Okada,, M. (1982): Increase of inactive form of aspartate aminotransferase in pyridoxine-deficient rat liver. J. Biochem., 92, 1079-1085. – reference: 21) Herzfeld, A., and Greengard, O. (1971): Aspartate aminotransferase in rat tissues: changes with growth and hormones. Biochim. Biophys. Acta, 237, 88-98. |
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| SubjectTerms | Animals aspartate aminotransferase Aspartate Aminotransferases Aspartate Aminotransferases - metabolism aspartate transaminase Cytosol Cytosol - enzymology enzymology Liver Liver - enzymology Malate Dehydrogenase Malate Dehydrogenase - metabolism Male malic enzyme metabolism Mitochondria, Liver Mitochondria, Liver - enzymology nutrient deficiencies pharmacology physiopathology pyridoxine pyridoxine deficiency Rats Rats, Inbred Strains thyroid function Thyroid Gland Thyroid Gland - physiopathology triiodothyronine triiodothyronine (T3) administration Triiodothyronine - pharmacology Vitamin B 6 Deficiency Vitamin B 6 Deficiency - enzymology |
| Title | Effect of administration of triiodothyronine on aspartate aminotransferase in pyridoxine-deficient rats |
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