The cullin4A is up-regulated in chronic obstructive pulmonary disease patient and contributes to epithelial-mesenchymal transition in small airway epithelium

• Published in: Respiratory research Vol. 20; no. 1; pp. 84 - 14
• Main Authors: Ren, Yidan, Zhang, Yi, Fan, Lixia, Jiao, Qinlian, Wang, Yunshan, Wang, Qin
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 06.05.2019; BioMed Central; BMC
• Subjects: Aged; Air flow; Asthma; Breast cancer; Care and treatment; Cell adhesion & migration; Cell cycle; Cells, Cultured; Cellular proteins; Chronic obstructive lung disease; Chronic obstructive pulmonary disease; Cigarette smoke; CUL4A; Cullin Proteins - biosynthesis; Development and progression; Disease; Epithelial cells; Epithelial-mesenchymal transition; Epithelial-Mesenchymal Transition - physiology; Epithelium; Female; Gene expression; Genetic aspects; Health aspects; Humans; Immunohistochemistry; Lung cancer; Lung diseases; Male; Mesenchyme; Metastasis; Middle Aged; Morbidity; Non-small cell lung carcinoma; Obstructive lung disease; Pathogenesis; Patients; Proteins; Pulmonary Disease, Chronic Obstructive - metabolism; Pulmonary Disease, Chronic Obstructive - pathology; Respiratory diseases; Respiratory Mucosa - metabolism; Respiratory Mucosa - pathology; Respiratory tract; Respiratory tract diseases; Retrospective Studies; Risk analysis; Risk factors; Small airway epithelial cells; Smoke; Smoking; Studies; Ubiquitin; Ubiquitin-protein ligase; Ventilation; China; CUL4A; Epithelial-mesenchymal transition; Chronic obstructive pulmonary disease; Cigarette smoke; Small airway epithelial cells

Chronic obstructive pulmonary disease (COPD) is a common respiratory disease with high morbidity and mortality. The most important pathophysiological change of COPD is airway obstruction. Airway obstruction can cause airflow restriction and obstructive ventilation dysfunction. Currently, many studie...