Efficacy and safety of dupilumab for the treatment of uncontrolled asthma: a meta-analysis of randomized clinical trials

• Published in: Respiratory research Vol. 20; no. 1; p. 108
• Main Authors: Xiong, Xiao-Feng, Zhu, Min, Wu, Hong-Xia, Fan, Li-Li, Cheng, De-Yun
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 31.05.2019; BioMed Central; BMC
• Subjects: Anti-Asthmatic Agents - therapeutic use; Antibodies, Monoclonal, Humanized - therapeutic use; Asthma; Asthma - diagnosis; Asthma - drug therapy; Asthma - physiopathology; Clinical trials; Collaboration; Control methods; Cytokines; Drug therapy; Dupilumab; Emergency medical care; Humans; Immunotherapy; Medical research; Meta-analysis; Monoclonal antibodies; Patient outcomes; Patients; Pharmaceutical research; Quality of life; Questionnaires; Randomization; Randomized control trial; Randomized Controlled Trials as Topic - methods; Respiratory Function Tests - methods; Risk assessment; Safety; Signs and symptoms; Studies; Treatment Outcome; Uncontrolled asthma; China; Dupilumab; Randomized control trial; Uncontrolled asthma; Meta-analysis

Several recent clinical trials have assessed the effects of dupilumab in uncontrolled asthma, but reached no definite conclusion. We therefore conducted this meta-analysis to evaluate the overall efficacy and safety of dupilumab for the treatment of uncontrolled asthma. All randomized controlled tri...