Human leukocyte antigen super-locus: nexus of genomic supergenes, SNPs, indels, transcripts, and haplotypes

• Published in: Human genome variation Vol. 9; no. 1; pp. 49 - 15
• Main Authors: Kulski, Jerzy K., Suzuki, Shingo, Shiina, Takashi
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 21.12.2022; Springer Nature B.V; Nature Publishing Group
• Subjects: 631/208/728; 692/308/2056; Antigens; Autoimmune diseases; Biomedical and Life Sciences; Biomedicine; Cell surface; Gene Expression; Gene Function; Gene Therapy; Genetic analysis; Genetic diversity; Genomics; Genotyping; Haplotypes; Histocompatibility antigen HLA; Human Genetics; Immune response; Major histocompatibility complex; Minority & ethnic groups; Molecular Medicine; Next-generation sequencing; Phenotypes; Population studies; Review; Review Article; Reviews; Single-nucleotide polymorphism; Transplantation; Transplants & implants

The human Major Histocompatibility Complex (MHC) or Human Leukocyte Antigen (HLA) super-locus is a highly polymorphic genomic region that encodes more than 140 coding genes including the transplantation and immune regulatory molecules. It receives special attention for genetic investigation because...