Altered Creatine Kinase Adenosine Triphosphate Kinetics in Failing Hypertrophied Human Myocardium

• Published in: Circulation (New York, N.Y.) Vol. 114; no. 11; pp. 1151 - 1158
• Main Authors: Smith, Craig S., Bottomley, Paul A., Schulman, Steven P., Gerstenblith, Gary, Weiss, Robert G.
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 12.09.2006
• Subjects: Adenosine Triphosphate - metabolism; Adult; Aged; Associated diseases and complications; Atherosclerosis (general aspects, experimental research); Biological and medical sciences; Blood and lymphatic vessels; Cardiac Output, Low - enzymology; Cardiac Output, Low - etiology; Cardiac Output, Low - physiopathology; Cardiology. Vascular system; Creatine Kinase - metabolism; Diabetes. Impaired glucose tolerance; Disease Progression; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Energy Metabolism - physiology; Female; Heart - physiopathology; Heart Ventricles - enzymology; Heart Ventricles - physiopathology; Humans; Hypertrophy, Left Ventricular - enzymology; Hypertrophy, Left Ventricular - etiology; Hypertrophy, Left Ventricular - physiopathology; Male; Medical sciences; Middle Aged; Myocardium - enzymology; Myocardium - pathology; Severity of Illness Index; Human; Heart failure; Hypertrophied heart; Purine nucleoside; Adenosine; Enzyme; Creatine kinase; hypertrophy; Transferases; Cardiovascular disease; magnetic resonance spectroscopy; NMR spectrometry; Triphosphates; Metabolism; Adenosine kinase; Heart disease; adenosine triphosphate

Background— The progression of pressure-overload left ventricular hypertrophy (LVH) to chronic heart failure (CHF) may involve a relative deficit in energy supply and/or delivery. Methods and Results— We measured myocardial creatine kinase (CK) metabolite concentrations and adenosine triphosphate (A...