An HIV Patient with Hepatic Flare after the Initiation of HBV-active Antiretroviral Therapy

• Published in: Internal Medicine Vol. 51; no. 12; pp. 1623 - 1626
• Main Authors: Yoshida, Masaki, Hoshina, Tokio, Tamura, Kumi, Kawano, Shinji, Kato, Tetsuro, Sato, Fumiya, Nakazawa, Yasushi, Yoshikawa, Koji, Onodera, Shoichi, Hori, Seiji
• Format: Journal Article
• Language: English
• Published: Japan The Japanese Society of Internal Medicine 01.01.2012
• Subjects: Adult; Alanine Transaminase - blood; Anti-HIV Agents - therapeutic use; antiretroviral therapy; Antiviral Agents - adverse effects; Aspartate Aminotransferases - blood; CD4 antigen; CD4 Lymphocyte Count; hepatic flare; Hepatitis B - complications; Hepatitis B - drug therapy; Hepatitis B - immunology; Hepatitis B - virology; Hepatitis B virus; Hepatitis B virus - genetics; Hepatitis B virus - isolation & purification; HIV Infections - complications; HIV Infections - immunology; HIV Infections - virology; Hospitals; Human immunodeficiency virus; human immunodeficiency virus (HIV); Humans; Immune reconstitution; immune reconstitution inflammatory syndrome (IRIS); Immune Reconstitution Inflammatory Syndrome - etiology; Immune Reconstitution Inflammatory Syndrome - immunology; Immune Reconstitution Inflammatory Syndrome - virology; Infection; Liver; Lymphocytes T; Male; resolved hepatitis B virus; RNA, Viral - blood; Viral Load

A 39-year-old man presented a CD4 T cell count of 78/μL and HIV-RNA at 6.6×105 copies/mL at his first medical examination. After the 58th day, we initiated HBV-active antiretroviral therapy. Three months after the start of antiretroviral therapy, he was diagnosed with hepatic flare on the basis of e...