The relationship between synovial inflammation, structural pathology, and pain in post-traumatic osteoarthritis: differential effect of stem cell and hyaluronan treatment

• Published in: Arthritis research & therapy Vol. 22; no. 1; p. 29
• Main Authors: Shu, Cindy C, Zaki, Sanaa, Ravi, Varshini, Schiavinato, Antonella, Smith, Margaret M, Little, Christopher B
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 14.02.2020; BioMed Central; BMC
• Subjects: Analgesia; Animals; Arthritis; Bone marrow; Care and treatment; Cartilage; Diagnosis; Disease; Diseases; Enzymes; Gene expression; Genes; Health aspects; Histochemistry; House mouse; Hyaluronan; Hyaluronic acid; Inflammation; Lymphocytes; Macrophages; Medical examination; Mesenchymal stem cells; Osteoarthritis; Pain; Pain management; Pathology; Patient outcomes; Polymerase chain reaction; Setting (Literature); Stem cell transplantation; Stem cells; Structural pathology; Surgery; Synovial inflammation; Synovial membrane; T cells; Time; Italy; Hyaluronan; Structural pathology; Pain; Osteoarthritis; Synovial inflammation; Mesenchymal stem cells

Synovitis is implicated in the severity and progression of pain and structural pathology of osteoarthritis (OA). Increases in inflammatory or immune cell subpopulations including macrophages and lymphocytes have been reported in OA synovium, but how the particular subpopulations influence symptomati...