Dissecting the role of non-coding RNAs in the accumulation of amyloid and tau neuropathologies in Alzheimer’s disease

• Published in: Molecular neurodegeneration Vol. 12; no. 1; pp. 51 - 13
• Main Authors: Patrick, Ellis, Rajagopal, Sathyapriya, Wong, Hon-Kit Andus, McCabe, Cristin, Xu, Jishu, Tang, Anna, Imboywa, Selina H., Schneider, Julie A., Pochet, Nathalie, Krichevsky, Anna M., Chibnik, Lori B., Bennett, David A., De Jager, Philip L.
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 01.07.2017; BioMed Central; BMC
• Subjects: Aging; Alzheimer Disease - genetics; Alzheimer Disease - metabolism; Alzheimer's disease; Amyloid beta-Peptides - metabolism; Amyloid Precursor Protein Secretases - metabolism; Amyloidogenic Proteins - metabolism; Bioinformatics; Brain - metabolism; Development and progression; DNA methylation; Female; Gene expression; Genetic aspects; Genomes; Genomics; Humans; lincRNA; Male; Memory; MicroRNA; MicroRNAs; miRNA; Neuritic β-amyloid plaques and neurofibrillary tangles; Neurodegeneration; Neurodegenerative diseases; Neurofibrillary Tangles - metabolism; Non-coding RNA; Nucleotide sequence; Ontology; Physiological aspects; Plaque, Amyloid - metabolism; Plaque, Amyloid - pathology; Prefrontal cortex; Proteins; Religious orders; RNA, Untranslated - metabolism; Senile plaques; Studies; Tau protein; tau Proteins - metabolism; β-Amyloid; United States; Neuritic β-amyloid plaques and neurofibrillary tangles; lincRNA; microRNA; Alzheimer’s disease

Given multiple studies of brain microRNA (miRNA) in relation to Alzheimer's disease (AD) with few consistent results and the heterogeneity of this disease, the objective of this study was to explore their mechanism by evaluating their relation to different elements of Alzheimer's disease p...