Plantainoside D Reduces Depolarization-Evoked Glutamate Release from Rat Cerebral Cortical Synaptosomes

• Published in: Molecules (Basel, Switzerland) Vol. 28; no. 3; p. 1313
• Main Authors: Chiu, Kuan-Ming, Lee, Ming-Yi, Lu, Cheng-Wei, Lin, Tzu-Yu, Wang, Su-Jane
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 30.01.2023; MDPI
• Subjects: 4-Aminopyridine - pharmacology; Alzheimer's disease; Analysis; Animals; Calcium - metabolism; Calcium Channel Blockers - pharmacology; Calcium ions; Calcium Signaling; cerebral cortex; Cerebral Cortex - metabolism; Enzymes; glutamate release; Glutamic Acid - metabolism; Health aspects; Homeostasis; Kinases; Neurophysiology; Neurotransmitters; Oxidative stress; Parkinson's disease; PKC; plantainoside D; Properties; Protein Kinase C - metabolism; Protein kinases; Proteins; Rats; Rats, Sprague-Dawley; synaptosomes; Synaptosomes - metabolism; voltage-dependent Ca2+ channel; Taiwan; voltage-dependent Ca2+ channel; cerebral cortex; PKC; plantainoside D; synaptosomes; glutamate release

Inhibiting the excessive release of glutamate in the brain is emerging as a promising therapeutic option and is efficient for treating neurodegenerative disorders. The aim of this study is to investigate the effect and mechanism of plantainoside D (PD), a phenylenthanoid glycoside isolated from Plan...