Plasma exosome microRNAs are indicative of breast cancer

• Published in: Breast cancer research : BCR Vol. 18; no. 1; p. 90
• Main Authors: Hannafon, Bethany N., Trigoso, Yvonne D., Calloway, Cameron L., Zhao, Y. Daniel, Lum, David H., Welm, Alana L., Zhao, Zhizhuang J., Blick, Kenneth E., Dooley, William C., Ding, W. Q.
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 08.09.2016; BioMed Central
• Subjects: Aged; Aged, 80 and over; Animals; Biological markers; Biomarkers, Tumor; Breast cancer; Breast Neoplasms - blood; Breast Neoplasms - genetics; Breast Neoplasms - metabolism; Breast Neoplasms - pathology; Case-Control Studies; Cell Line, Tumor; Culture Media, Conditioned - metabolism; Diagnosis; Disease Models, Animal; Exosomes - genetics; Exosomes - metabolism; Female; Gene Expression Profiling; Genetic aspects; Heterografts; Humans; Mice; MicroRNA; MicroRNAs - genetics; Middle Aged; Neoplasm Grading; Neoplasm Staging; ROC Curve; Xenotransplantation; Taiwan; microRNA; Biomarker; Breast cancer; Exosomes; Patient-derived xenograft

microRNAs are promising candidate breast cancer biomarkers due to their cancer-specific expression profiles. However, efforts to develop circulating breast cancer biomarkers are challenged by the heterogeneity of microRNAs in the blood. To overcome this challenge, we aimed to develop a molecular pro...