Hsa_circ_0046264 up-regulated BRCA2 to suppress lung cancer through targeting hsa-miR-1245

• Published in: Respiratory research Vol. 19; no. 1; p. 115
• Main Authors: Yang, Liu, Wang, Jun, Fan, Yaodong, Yu, Kun, Jiao, Baowei, Su, Xiaosan
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 11.06.2018; BioMed Central; BMC
• Subjects: Apoptosis; Assaying; Bioinformatics; BRCA2; BRCA2 protein; Breast cancer; Cancer; Cancer therapies; Cell proliferation; Chemotherapy; Circular RNA; Deoxyribonucleic acid; Diagnosis; DNA; DNA damage; DNA microarrays; Flow cytometry; Gene expression; Genes; Genetic aspects; Hsa-miR-1245; hsa_circ_0046264; Immunohistochemistry; Lung cancer; Metastasis; MicroRNA; Molecular chains; Molecular modelling; Mutation; Ovarian cancer; Patient outcomes; Proteins; Ribonuclease; Ribonucleic acid; RNA; Tumor suppressor genes; Tumors; United States > US; China; Hsa-miR-1245; BRCA2; Lung cancer; hsa_circ_0046264

Lung cancer had been leading mounts of deaths worldwide. Advances in genes microarray had helped human further understand genes and identify novel circular RNAs. This study aimed at investigating the biological functions and molecular mechanisms of hsa_circ_0046264 in lung cancer which may be helpfu...