Baicalin ameliorates neuroinflammation-induced depressive-like behavior through inhibition of toll-like receptor 4 expression via the PI3K/AKT/FoxO1 pathway

• Published in: Journal of neuroinflammation Vol. 16; no. 1; pp. 95 - 21
• Main Authors: Guo, Li-Ting, Wang, Si-Qi, Su, Jing, Xu, Li-Xing, Ji, Zhou-Ye, Zhang, Ru-Yi, Zhao, Qin-Wen, Ma, Zhan-Qiang, Deng, Xue-Yang, Ma, Shi-Ping
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 08.05.2019; BioMed Central; BMC
• Subjects: 1-Phosphatidylinositol 3-kinase; AKT protein; Analysis; Animals; Anti-Inflammatory Agents - pharmacology; Baicalin; Behavior; Brain research; Central nervous system; Central nervous system diseases; Complications and side effects; Cytokines; Depression; Depression - etiology; Depression - immunology; Depression, Mental; Drug therapy; Enzyme-linked immunosorbent assay; Flavonoids - pharmacology; Forkhead Box Protein O1 - metabolism; Forkhead protein; FoxO1; FOXO1 protein; Gene expression; IL-1β; Inflammation; Inflammation - metabolism; Interleukin 1; Interleukin 6; Kinases; Lipopolysaccharides; Male; Mental depression; Mice; Mice, Inbred ICR; Microglia; Microglial cells; Molecular modelling; Nervous system diseases; Neuroinflammation; Neuroprotective agents; Phosphatidylinositol 3-Kinases - metabolism; Phosphorylation; Physiological aspects; Proto-Oncogene Proteins c-akt - metabolism; Psychological Distress - complications; Psychological Distress - immunology; Risk factors; Signal Transduction - drug effects; siRNA; Testing; TLR4; TLR4 protein; Toll-Like Receptor 4 - biosynthesis; Toll-Like Receptor 4 - drug effects; Toll-like receptors; Transcription factors; Tumor necrosis factor-TNF; Tumor necrosis factor-α; China; United States > US; Depression; Neuroinflammation; TLR4; Baicalin; FoxO1

Baicalin, which is isolated from Radix Scutellariae, possesses strong biological activities including an anti-inflammation property. Recent studies have shown that the anti-inflammatory effect of baicalin is linked to toll-like receptor 4 (TLR4), which participates in pathological changes of central...