Baicalin ameliorates neuroinflammation-induced depressive-like behavior through inhibition of toll-like receptor 4 expression via the PI3K/AKT/FoxO1 pathway - Guo, Li-Ting; Wang, Si-Qi; Su, Jing; Xu, Li-Xing; Ji, Zhou-Ye; Zhang, Ru-Yi; Zhao, Qin-Wen; Ma, Zhan-Qiang; Deng, Xue-Yang; Ma, Shi-Ping (Journal of neuroinflammation, 2019)
Keywords: 1-Phosphatidylinositol 3-kinase; AKT protein; Analysis; Animals; Anti-Inflammatory Agents - pharmacology; Baicalin; Behavior; Brain research; Central nervous system; Central nervous system diseases; Complications and side effects; Cytokines; Depression; Depression - etiology; Depression - immunology; Depression, Mental; Drug therapy; Enzyme-linked immunosorbent assay; Flavonoids - pharmacology; Forkhead Box Protein O1 - metabolism; Forkhead protein; FoxO1; FOXO1 protein; Gene expression; IL-1β; Inflammation; Inflammation - metabolism; Interleukin 1; Interleukin 6; Kinases; Lipopolysaccharides; Male; Mental depression; Mice; Mice, Inbred ICR; Microglia; Microglial cells; Molecular modelling; Nervous system diseases; Neuroinflammation; Neuroprotective agents; Phosphatidylinositol 3-Kinases - metabolism; Phosphorylation; Physiological aspects; Proto-Oncogene Proteins c-akt - metabolism; Psychological Distress - complications; Psychological Distress - immunology; Risk factors; Signal Transduction - drug effects; siRNA; Testing; TLR4; TLR4 protein; Toll-Like Receptor 4 - biosynthesis; Toll-Like Receptor 4 - drug effects; Toll-like receptors; Transcription factors; Tumor necrosis factor-TNF; Tumor necrosis factor-α; China; United States--US; Depression; Neuroinflammation; TLR4; Baicalin; FoxO1