Choice of futility boundaries for group sequential designs with two endpoints - Schüler, Svenja; Kieser, Meinhard; Rauch, Geraldine (BMC medical research methodology, 2017)
Keywords: Algorithms; Analysis; Biometrics; Choice Behavior; Clinical trials; Clinical Trials as Topic - methods; Clinical Trials as Topic - standards; Endpoint Determination - methods; Endpoint Determination - standards; Group sequential design; Humans; Hypotheses; Intersection-union test; Medical Futility; Models, Statistical; Monte Carlo Method; Pharmaceutical industry; Principles; Probability; Research Design - standards; Stopping for futility; Two endpoints; Group sequential design; Stopping for futility; Intersection-union test; Two endpoints