Characteristics and genomic epidemiology of colistin-resistant Enterobacterales from farmers, swine, and hospitalized patients in Thailand, 2014–2017

• Published in: BMC infectious diseases Vol. 23; no. 1; pp. 1 - 556
• Main Authors: Boonyasiri, Adhiratha, Brinkac, Lauren M, Jauneikaite, Elita, White, Richard C, Greco, Chris, Seenama, Chakkraphong, Tangkoskul, Teerawit, Nguyen, Kevin, Fouts, Derrick E, Thamlikitkul, Visanu
• Format: Journal Article
• Language: English
• Published: London BioMed Central Ltd 28.08.2023; BioMed Central; BMC
• Subjects: Amides; Analysis; Antibacterial agents; Antibiotics; Antimicrobial agents; Antimicrobial resistance; Bacteria; Beta lactam antibiotics; Beta lactamases; Carbapenemase; Carbapenemase-producing Enterobacterales; Care and treatment; Colistin; Colistin resistance; Control; Dosage and administration; Drug resistance in microorganisms; E coli; Enterobacter; Enterobacterales; Enterobacteriaceae; Epidemiology; Escherichia coli; Farmers; Farms; Farmworkers; Genes; Genomes; Genomic analysis; Genomic epidemiology; Gram-negative bacteria; Health aspects; Hospital patients; Hospitalization; Identification and classification; Incompatibility; Infections; Ions; Klebsiella; Livestock; Livestock farming; Livestock farms; Multilocus sequence typing; Patients; Phylogenetics; Plasmids; Pork industry; Prevention; Proteins; Strains (organisms); Surveillance; Swine; β Lactamase; β-Lactam antibiotics; Thailand; China; United States > US

Colistin is one of the last resort therapeutic options for treating carbapenemase-producing Enterobacterales, which are resistant to a broad range of beta-lactam antibiotics. However, the increased use of colistin in clinical and livestock farming settings in Thailand and China, has led to the inevi...