Nanobody Conjugates for Targeted Cancer Therapy and Imaging

• Published in: Technology in cancer research & treatment Vol. 20; p. 15330338211010117
• Main Authors: Kang, Wei, Ding, Chuanfeng, Zheng, Danni, Ma, Xiao, Yi, Lun, Tong, Xinyi, Wu, Chuang, Xue, Chuang, Yu, Yongsheng, Zhou, Qian
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 01.01.2021; Sage Publications Ltd; SAGE Publishing
• Subjects: Amino acids; Antibodies; Antigens; Binding sites; Bioengineering; Cancer; Cancer research; Cancer therapies; Chemical bonds; Crystal structure; Cytotoxicity; Epidermal growth factor; Fluorophores; Immunogenicity; Medical research; Nanobodies; Pharmacokinetics; Proteins; Review; Side effects; Targeted cancer therapy; Tomography; Toxins; Tumor cells; antibody fragments; therapeutic nanobodies; targeted caner treatment; nanobodies; bioconjugations; cancer imaging

Conventional antibody-based targeted cancer therapy is one of the most promising avenues of successful cancer treatment, with the potential to reduce toxic side effects to healthy cells surrounding tumor cells. However, the full potential of antibodies is severely limited due to their large size, lo...