Glial phagocytic clearance in Parkinson’s disease

• Published in: Molecular neurodegeneration Vol. 14; no. 1; pp. 16 - 14
• Main Authors: Tremblay, Marie-Eve, Cookson, Mark R., Civiero, Laura
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 05.04.2019; BioMed Central; BMC
• Subjects: Apoptosis; Astrocytes; Astrocytes - metabolism; Brain; Chemokines; Cytokines; Disease; Genetic diversity; Glial cells; Humans; Kinases; Microglia; Microglia - metabolism; Molecular modelling; Movement disorders; Mutation; Nervous system; Neurodegeneration; Neurodegenerative diseases; Neurodegenerative Diseases - metabolism; Neurodegenerative Diseases - pathology; Neuroglia - metabolism; Neuronal-glial interactions; Neurons; Parkinson Disease - metabolism; Parkinson's disease; Pathogenesis; Pathology; Phagocytes; Phagocytosis; Phagocytosis - physiology; Physiology; Proteins; Reactive astrocytes; Reactive microglia; Review; Synapses; Synapses - metabolism; Target recognition; Reactive microglia; Parkinson’s disease; Phagocytosis; Reactive astrocytes

An emerging picture suggests that glial cells' loss of beneficial roles or gain of toxic functions can contribute to neurodegenerative conditions. Among glial cells, microglia and astrocytes have been shown to play phagocytic roles by engulfing synapses, apoptotic cells, cell debris, and releas...