The combination of procalcitonin and C-reactive protein or presepsin alone improves the accuracy of diagnosis of neonatal sepsis: a meta-analysis and systematic review

• Published in: Critical care (London, England) Vol. 22; no. 1; pp. 316 - 9
• Main Authors: Ruan, Lin, Chen, Guan-Yu, Liu, Zhen, Zhao, Yun, Xu, Guang-Yu, Li, Shu-Fang, Li, Chun-Ni, Chen, Lin-Shan, Tao, Zheng
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 21.11.2018; BioMed Central; BMC
• Subjects: Accuracy; Antibiotics; Bacterial infections; Bias; Biomarkers; Blood tests; C-reactive protein; Critical care; Diagnosis; Drug resistance; Infections; Medical diagnosis; Meta-analysis; Neonatal diseases; Neonatal sepsis; Newborn babies; Patients; Procalcitonin; Proteins; Sepsis; Software; Systematic review; Viral infections; China; Systematic review; C-reactive protein; Procalcitonin; Meta-analysis; Neonatal sepsis

Sepsis is an important cause of neonatal morbidity and mortality; therefore, the early diagnosis of neonatal sepsis is essential. Our aim was to compare the diagnostic accuracy of procalcitonin (PCT), C-reactive protein (CRP), procalcitonin combined with C-reactive protein (PCT + CRP) and presepsin...