Long non-coding RNA linc00673 regulated non-small cell lung cancer proliferation, migration, invasion and epithelial mesenchymal transition by sponging miR-150-5p

• Published in: Molecular cancer Vol. 16; no. 1; pp. 118 - 14
• Main Authors: Lu, Wei, Zhang, Honghe, Niu, Yuequn, Wu, Yongfeng, Sun, Wenjie, Li, Hongyi, Kong, Jianlu, Ding, Kefeng, Shen, Han-Ming, Wu, Han, Xia, Dajing, Wu, Yihua
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 11.07.2017; BioMed Central; BMC
• Subjects: Adenocarcinoma; Apoptosis - genetics; Base Sequence; Bioinformatics; Biomarkers; Cancer therapies; Carcinoma, Non-Small-Cell Lung - genetics; Carcinoma, Non-Small-Cell Lung - pathology; Cell cycle; Cell growth; Cell Line, Tumor; Cell migration; Cell Movement - genetics; Cell proliferation; Cell Proliferation - genetics; Cell Survival - genetics; Cholecystokinin; Colorectal cancer; Competing endogenous RNA; Deoxyribonucleic acid; Development and progression; DNA; Epigenetics; Epithelial mesenchymal transition; Epithelial-Mesenchymal Transition - genetics; Esophagus; Gene Expression Regulation, Neoplastic; Genetic aspects; Humans; Immunofluorescence; linc00673; Liver cancer; Lung cancer; Lung cancer, Non-small cell; Lung Neoplasms - genetics; Lung Neoplasms - pathology; Malignancy; Medical prognosis; Mesenchyme; Metastasis; MicroRNA; MicroRNAs - genetics; MicroRNAs - metabolism; miR-150-5p; miRNA; Models, Biological; Neoplasm Invasiveness; Non-coding RNA; Non-small cell lung cancer; Non-small cell lung carcinoma; Pancreas; Pancreatic cancer; Physiological aspects; Polymerase chain reaction; Prognosis; RNA, Long Noncoding - genetics; RNA, Long Noncoding - metabolism; Studies; Survival Analysis; Transforming growth factors; Tumorigenesis; Zinc Finger E-box-Binding Homeobox 1 - genetics; Zinc Finger E-box-Binding Homeobox 1 - metabolism; China; linc00673; Epithelial mesenchymal transition; miR-150-5p; Competing endogenous RNA; Non-small cell lung cancer

The function of a new long non-coding RNA linc00673 remains unclear. While identified as an oncogenic player in non-small cell lung cancer (NSCLC), linc00673 was found to be anti-oncogenic in pancreatic ductal adenocarcinoma (PDAC). However whether linc00673 regulated malignancy and epithelial mesen...