Towards precision medicine: discovering novel gynecological cancer biomarkers and pathways using linked data

• Published in: Journal of biomedical semantics Vol. 8; no. 1; pp. 40 - 16
• Main Authors: Jha, Alokkumar, Khan, Yasar, Mehdi, Muntazir, Karim, Md Rezaul, Mehmood, Qaiser, Zappa, Achille, Rebholz-Schuhmann, Dietrich, Sahay, Ratnesh
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 19.09.2017; BioMed Central; BMC
• Subjects: Adenocarcinoma; Adhesives; Annotations; Automation; Bioinformatics; Biomarkers; Biomarkers, Tumor - metabolism; Cancer; Cancer genomics; Care and treatment; Cell cycle; Cervical cancer; Cervix; Clinical outcomes; Copy number; Data links; Data Mining; Databases, Factual; Datasets; Decision making; DNA methylation; Electronic health records; Endometrial cancer; Endometrium; Epigenetics; Female; Gene expression; Genes; Genital Diseases, Female - metabolism; Genomes; Genomics; Glues; Gynecological cancer; Gynecology; Human body; Humans; Life sciences; Linked data; Medical Informatics - methods; Medical research; Multi-Omics; Mutation; Ovarian cancer; Pathways; Precision medicine; Precision Medicine - methods; Repositories; Squamous cell carcinoma; Studies; Tumorigenesis; Uterine cancer; Uterus; Multi-Omics; Linked data; Pathways; Biomarkers; Gynecological cancer; Semantic technologies; Cancer genomics

Next Generation Sequencing (NGS) is playing a key role in therapeutic decision making for the cancer prognosis and treatment. The NGS technologies are producing a massive amount of sequencing datasets. Often, these datasets are published from the isolated and different sequencing facilities. Consequ...