Cell and neuron densities in the primary motor cortex of primates

• Published in: Frontiers in neural circuits Vol. 7; p. 30
• Main Authors: Young, Nicole A, Collins, Christine E, Kaas, Jon H
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Research Foundation 2013; Frontiers Media S.A
• Subjects: Animals; Brain research; Cell Count - methods; Cortex (motor); Dissection; Electric Stimulation - methods; flow fractionator; Galago; isotrophic fractionator; isotropic fractionator; Macaca nemestrina; Monkeys & apes; Motor Cortex - cytology; Motor Cortex - physiology; Movement; neuron distribution; Neurons; Neurons - physiology; Neuroscience; Pan troglodytes; Papio cynocephalus; Papio hamadryas; Platyrrhini; Primates; Saimiri; Species; Species Specificity; Strepsirhini; isotropic fractionator; flow fractionator; M1; movement
• DOI: 10.3389/fncir.2013.00030
• ISSN: 1662-5110

Cell and neuron densities vary across the cortical sheet in a predictable manner across different primate species (Collins et al., 2010b). Primary motor cortex, M1, is characterized by lower neuron densities relative to other cortical areas. M1 contains a motor representation map of contralateral body parts from tail to tongue in a mediolateral sequence. Different functional movement representations within M1 likely require specialized microcircuitry for control of different body parts, and these differences in circuitry may be reflected by variation in cell and neuron densities. Here we determined cell and neuron densities for multiple sub-regions of M1 in six primate species, using the semi-automated flow fractionator method. The results verify previous reports of lower overall neuron densities in M1 compared to other parts of cortex in the six primate species examined. The most lateral regions of M1 that correspond to face and hand movement representations, are more neuron dense relative to medial locations in M1, which suggests differences in cortical circuitry within movement zones.