Effects of Brazilian green propolis on proteinuria and renal function in patients with chronic kidney disease: a randomized, double-blind, placebo-controlled trial

• Published in: BMC nephrology Vol. 20; no. 1; pp. 140 - 12
• Main Authors: Silveira, Marcelo Augusto Duarte, Teles, Flávio, Berretta, Andressa A., Sanches, Talita R., Rodrigues, Camila Eleutério, Seguro, Antonio Carlos, Andrade, Lúcia
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 25.04.2019; BioMed Central; BMC
• Subjects: Age; Anti-Inflammatory Agents - administration & dosage; Anti-Inflammatory Agents - adverse effects; Antioxidants - administration & dosage; Antioxidants - adverse effects; Blood pressure; Care and treatment; Chronic kidney failure; Creatinine; Development and progression; Diabetes; Diabetes mellitus; Disease Progression; Double-blind studies; Drugs; Enzymes; Epidermal growth factor receptors; Etiology; Excretion; Female; Forecasts and trends; Glomerular filtration rate; Glomerular Filtration Rate - drug effects; Health aspects; Humans; Hypertension; Immunomodulation; Inflammation; Kidney diseases; Male; Middle Aged; Monocyte chemoattractant protein; Monocyte chemoattractant protein 1; Monocytes; Mortality; Nephrology; Plant Exudates - administration & dosage; Plant Exudates - adverse effects; Propolis; Propolis - administration & dosage; Propolis - adverse effects; Proteins; Proteinuria; Proteinuria - diagnosis; Proteinuria - drug therapy; Proteinuria - etiology; Public health; Renal Elimination - drug effects; Renal function; Renal Insufficiency, Chronic - diagnosis; Renal Insufficiency, Chronic - drug therapy; Renal Insufficiency, Chronic - urine; Transplants & implants; Treatment Outcome; Brazil

Chronic kidney disease (CKD) is a public health problem worldwide, and proteinuria is a well-established marker of disease progression in CKD patients. Propolis, a natural resin produced by bees from plant materials, has anti-inflammatory, immunomodulatory, and anti-oxidant properties, as well as ha...