Synthesis and Preclinical Evaluation of Small-Molecule Prostate-Specific Membrane Antigen-Targeted Abiraterone Conjugate - Machulkin, Aleksei E.; Nimenko, Ekaterina A.; Zyk, Nikolay U.; Uspenskaia, Anastasiia A.; Smirnova, Galina B.; Khan, Irina I.; Pokrovsky, Vadim S.; Vaneev, Alexander N.; Timoshenko, Roman V.; Mamed-Nabizade, Vugara V.; Zavertkina, Maria V.; Erofeev, Alexander; et al. (Molecules (Basel, Switzerland), 2022)
Keywords: abiraterone; Adrenal glands; Androgen Antagonists; Androgens; Androstenes - pharmacology; Antibody-drug conjugates; Antigens; Antigens, Surface; Apoptosis; Cancer therapies; Chemotherapy; Cytochrome; Cytotoxicity; drug delivery; Drug therapy; Enzymes; Fibroblasts; Health aspects; Humans; Ligands; Male; Pharmaceuticals; Production processes; Prostate - pathology; Prostate cancer; Prostate-specific antigen; prostate-specific membrane antigen; Prostatic Neoplasms - drug therapy; Prostatic Neoplasms - pathology; Reactive oxygen species; Toxicity; Tumors; Russia; United States--US; prostate cancer; abiraterone; drug delivery; prostate-specific membrane antigen