Manganese Superoxide Dismutase (SOD2) Polymorphisms, Plasma Advanced Oxidation Protein Products (AOPP) Concentration and Risk of Kidney Complications in Subjects with Type 1 Diabetes

• Published in: PloS one Vol. 9; no. 5; p. e96916
• Main Authors: Mohammedi, Kamel, Bellili-Muñoz, Naïma, Driss, Fathi, Roussel, Ronan, Seta, Nathalie, Fumeron, Frédéric, Hadjadj, Samy, Marre, Michel, Velho, Gilberto
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 12.05.2014; Public Library of Science (PLoS)
• Subjects: Adult; Advanced Oxidation Protein Products - blood; Alleles; Antioxidants; Biochemistry; Biochemistry, Molecular Biology; Biology and Life Sciences; Complications; Cross-Sectional Studies; Diabetes; Diabetes mellitus; Diabetes Mellitus, Type 1 - blood; Diabetes Mellitus, Type 1 - complications; Diabetes Mellitus, Type 1 - genetics; Diabetic Nephropathies - blood; Diabetic Nephropathies - etiology; Diabetic Nephropathies - genetics; Diabetic nephropathy; Diabetic retinopathy; Endocrinology; Endocrinology and metabolism; Enzymes; Epidermal growth factor receptors; Female; Genomics; Glomerular filtration rate; Haplotypes; Human health and pathology; Humans; Incidence; Kaplan-Meier Estimate; Kidney diseases; Kidney transplantation; Kidneys; Life Sciences; Male; Manganese; Medicine and Health Sciences; Metabolism; Middle Aged; Mitochondria; Nephropathy; Nutrition; Oxidation; Oxidative stress; Oxidative Stress - genetics; Oxygen; Plasma; Prospective Studies; Proteins; Reactive oxygen species; Research and Analysis Methods; Retinopathy; Rodents; Single-nucleotide polymorphism; Superoxide dismutase; Superoxide Dismutase - blood; Superoxide Dismutase - genetics; Urology and Nephrology; Young Adult; France

Oxidative stress is involved in the pathophysiology of diabetic nephropathy. Manganese superoxide dismutase (SOD2) catalyses the dismutation of superoxide, regulates the metabolism of reactive oxygen species in the mitochondria and is highly expressed in the kidney. Plasma concentration of advanced...