Cholesterol Regulation of Membrane Proteins Revealed by Two-Color Super-Resolution Imaging

• Published in: Membranes (Basel) Vol. 13; no. 2; p. 250
• Main Authors: Yuan, Zixuan, Hansen, Scott B.
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.02.2023; MDPI
• Subjects: Alzheimer's disease; Binding sites; Biological control systems; Biological transport; Channel gating; Cholesterol; Cholesterol metabolism; Clustering; Color; Cytokines; Enzymes; Health aspects; Hydrophobicity; Image resolution; Inositol; Inositols; ion channel; Ion channels; Ligands; lipid raft; Lipids; Localization; Medical research; Medicine, Experimental; Membrane lipids; Membrane proteins; Membranes; Microscope and microscopy; nanoscopic; Nanotechnology; Optical properties; Phosphatidylinositol 4,5-diphosphate; Physiological aspects; PIP2; Potassium; Proteins; Review; Substrates; transporter; United States; nanoscopic; clustering; lipid raft; ion channel; PIP2; transporter

Cholesterol and phosphatidyl inositol 4,5-bisphosphate (PIP2) are hydrophobic molecules that regulate protein function in the plasma membrane of all cells. In this review, we discuss how changes in cholesterol concentration cause nanoscopic (<200 nm) movements of membrane proteins to regulate the...