A Targeting Nanotherapy for Abdominal Aortic Aneurysms

• Published in: Journal of the American College of Cardiology Vol. 72; no. 21; pp. 2591 - 2605
• Main Authors: Cheng, Juan, Zhang, Runjun, Li, Chenwen, Tao, Hui, Dou, Yin, Wang, Yuquan, Hu, Houyuan, Zhang, Jianxiang
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 27.11.2018; Elsevier Limited
• Subjects: Abdomen; aneurysm; Aneurysms; Animals; Aortic Aneurysm, Abdominal - drug therapy; Aortic Aneurysm, Abdominal - metabolism; Aortic Aneurysm, Abdominal - pathology; Aortic aneurysms; Apoptosis; Calcification; Cardiology; Cardiovascular; Cell adhesion & migration; Cell membranes; Cells, Cultured; Clinical trials; Coronary vessels; Drug Delivery Systems - methods; Drug development; Drugs; Efficiency; Experiments; Flow cytometry; Geriatrics; Immunosuppressive Agents - administration & dosage; Inflammation; Laboratory animals; Ligands; Macrophages; Male; Mice; Morbidity; Mortality; Muscle, Smooth, Vascular - drug effects; Muscle, Smooth, Vascular - metabolism; Muscle, Smooth, Vascular - pathology; Myocytes, Smooth Muscle - drug effects; Myocytes, Smooth Muscle - metabolism; Myocytes, Smooth Muscle - pathology; Nanoparticles; Nanoparticles - administration & dosage; nanotherapy; Oxidative stress; Peptides; Random Allocation; Rapamycin; Rats; Rats, Sprague-Dawley; RAW 264.7 Cells; Reactive oxygen species; Reactive Oxygen Species - antagonists & inhibitors; Reactive Oxygen Species - metabolism; Rodents; Sirolimus - administration & dosage; Statistical analysis; targeting; Vascular diseases; DHE; RAP; aneurysm; NP; nanotherapy; OxbCD; TNF; IFN; OCy5 NP; targeting; inflammation; Ca/Pi; reactive oxygen species; OR NP; AAA; ROR NP; IL; CMV; IV; PR NP; MMP; PEG; ROS; MCP; VSMC; CROR NP; reactive oxygen species–responsive, cRGDfK targeted rapamycin nanotherapy; cell membrane vesicle; abdominal aortic aneurysm; oxidation-responsive β-cyclodextrin material; intravenous; interleukin; monocyte chemoattractant protein; polyethylene glycol; calcium and inorganic phosphorus; nanoparticle; PLGA-derived rapamycin nanotherapy; interferon; Cy5-labeled OxbCD nanoparticle; tumor necrosis factor; dihydroethidium; matrix metalloproteinase; reactive oxygen species–responsive rapamycin nanotherapy; vascular smooth muscle cell; a reactive oxygen species–responsive, cRGDfK targeted, and macrophage cell membrane-coated rapamycin nanotherapy; rapamycin

Abdominal aortic aneurysm (AAA) is a leading cause of mortality and morbidity in the elderly. Currently, there remain no effective drugs that can prevent the growth of aneurysms and delay aneurysm rupture in the clinical setting. The aim of this study was to develop a nanotherapy that can target ane...