A Targeting Nanotherapy for Abdominal Aortic Aneurysms - Cheng, Juan; Zhang, Runjun; Li, Chenwen; Tao, Hui; Dou, Yin; Wang, Yuquan; Hu, Houyuan; Zhang, Jianxiang (Journal of the American College of Cardiology, 2018)
Keywords: Abdomen; aneurysm; Aneurysms; Animals; Aortic Aneurysm, Abdominal - drug therapy; Aortic Aneurysm, Abdominal - metabolism; Aortic Aneurysm, Abdominal - pathology; Aortic aneurysms; Apoptosis; Calcification; Cardiology; Cardiovascular; Cell adhesion & migration; Cell membranes; Cells, Cultured; Clinical trials; Coronary vessels; Drug Delivery Systems - methods; Drug development; Drugs; Efficiency; Experiments; Flow cytometry; Geriatrics; Immunosuppressive Agents - administration & dosage; Inflammation; Laboratory animals; Ligands; Macrophages; Male; Mice; Morbidity; Mortality; Muscle, Smooth, Vascular - drug effects; Muscle, Smooth, Vascular - metabolism; Muscle, Smooth, Vascular - pathology; Myocytes, Smooth Muscle - drug effects; Myocytes, Smooth Muscle - metabolism; Myocytes, Smooth Muscle - pathology; Nanoparticles; Nanoparticles - administration & dosage; nanotherapy; Oxidative stress; Peptides; Random Allocation; Rapamycin; Rats; Rats, Sprague-Dawley; RAW 264.7 Cells; Reactive oxygen species; Reactive Oxygen Species - antagonists & inhibitors; Reactive Oxygen Species - metabolism; Rodents; Sirolimus - administration & dosage; Statistical analysis; targeting; Vascular diseases; DHE; RAP; aneurysm; NP; nanotherapy; OxbCD; TNF; IFN; OCy5 NP; targeting; inflammation; Ca/Pi; reactive oxygen species; OR NP; AAA; ROR NP; IL; CMV; IV; PR NP; MMP; PEG; ROS; MCP; VSMC; CROR NP; reactive oxygen species–responsive, cRGDfK targeted rapamycin nanotherapy; cell membrane vesicle; abdominal aortic aneurysm; oxidation-responsive β-cyclodextrin material; intravenous; interleukin; monocyte chemoattractant protein; polyethylene glycol; calcium and inorganic phosphorus; nanoparticle; PLGA-derived rapamycin nanotherapy; interferon; Cy5-labeled OxbCD nanoparticle; tumor necrosis factor; dihydroethidium; matrix metalloproteinase; reactive oxygen species–responsive rapamycin nanotherapy