Regulation of Platelet-derived Growth Factor Receptor Function by Integrin-associated Cell Surface Transglutaminase

• Published in: The Journal of biological chemistry Vol. 284; no. 24; pp. 16693 - 16703
• Main Authors: Zemskov, Evgeny A., Loukinova, Elena, Mikhailenko, Irina, Coleman, Richard A., Strickland, Dudley K., Belkin, Alexey M.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 12.06.2009; American Society for Biochemistry and Molecular Biology
• Subjects: Animals; Cell Adhesion - physiology; Cell Division - physiology; Cell Movement - physiology; Cells, Cultured; Dermis - cytology; Down-Regulation - physiology; Fibroblasts - cytology; Fibroblasts - enzymology; Humans; Integrins - metabolism; Mechanisms of Signal Transduction; Mice; NIH 3T3 Cells; Receptor Aggregation - physiology; Receptor, Platelet-Derived Growth Factor beta - genetics; Receptor, Platelet-Derived Growth Factor beta - metabolism; Receptors, Cell Surface - metabolism; Signal Transduction - physiology; Transglutaminases - genetics; Transglutaminases - metabolism; Up-Regulation - physiology; Wound Healing - physiology

A functional collaboration between growth factor receptors such as platelet derived growth factor receptor (PDGFR) and integrins is required for effective signal transduction in response to soluble growth factors. However, the mechanisms of synergistic PDGFR/integrin signaling remain poorly understo...