Pulsed high-dose dexamethasone modulates Th1-/Th2-chemokine imbalance in immune thrombocytopenia

• Published in: Journal of translational medicine Vol. 14; no. 1; p. 301
• Main Authors: Liu, Zongtang, Wang, Meiying, Zhou, Shufen, Ma, Ji, Shi, Yan, Peng, Jun, Hou, Ming, Guo, Chengshan
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 24.10.2016; BioMed Central; BMC
• Subjects: Adolescent; Adult; Aged; Care and treatment; Chemokine; Chemokine receptor; Chemokines; Chemokines - blood; Chemokines - genetics; Chemokines - metabolism; Child; Dexamethasone; Dexamethasone - pharmacology; Dexamethasone - therapeutic use; Dosage and administration; Dose-Response Relationship, Drug; Female; Gene expression; Health aspects; High-dose dexamethasone; Humans; Immune thrombocytopenia; Male; Middle Aged; Purpura, Thrombocytopenic, Idiopathic - blood; Purpura, Thrombocytopenic, Idiopathic - drug therapy; Purpura, Thrombocytopenic, Idiopathic - genetics; Receptors, Chemokine - genetics; Receptors, Chemokine - metabolism; RNA, Messenger - genetics; RNA, Messenger - metabolism; Th1 Cells - drug effects; Th1 Cells - immunology; Th1 polarization; Th2 Cells - drug effects; Th2 Cells - immunology; Thrombocytopenia; Young Adult; China; Chemokine; Th1 polarization; Chemokine receptor; High-dose dexamethasone; Immune thrombocytopenia

Chemokines and chemokine receptors play important roles in autoimmune diseases; however, their role in immune thrombocytopenia (ITP) is unclear. High-dose dexamethasone (HD-DXM) may become a first-line therapy for adult patients with ITP, but the effect of HD-DXM on chemokines in ITP patients is unk...